Pharmacogenetic Polygenic Risk Score for Bronchodilator Response in Children and Adolescents with Asthma: Proof-of-Concept

Pharmacogenetic Polygenic Risk Score for Bronchodilator Response in Children and Adolescents with Asthma: Proof-of-Concept

Genome-wide association studies (GWAS) of response to asthma medications have primarily focused on Caucasian populations, with findings that may not be generalizable to minority populations. We derived a polygenic risk score (PRS) for response to albuterol as measured by bronchodilator response (BDR...

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Bibliographic Details
Main Authors: Joanne E. Sordillo, Sharon M. Lutz, Michael J. McGeachie, Jessica Lasky-Su, Scott T. Weiss, Juan C. Celedón, Ann Chen Wu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Personalized Medicine
Subjects:
bronchodilator response
genome-wide interaction study
asthma
Online Access:https://www.mdpi.com/2075-4426/11/4/319

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