The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy
Abstract Aims Establishing a diagnosis of inflammatory cardiomyopathy (iCMP) by non‐invasive means remains challenging despite advances in cardiac magnetic resonance imaging. Previous studies suggested the involvement of microRNAs in the pathogenesis of iCMP. We examined the association of a predefi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13304 |
| _version_ | 1797976450651914240 |
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| author | Danilo Obradovic Karl‐Philipp Rommel Stephan Blazek Karin Klingel Matthias Gutberlet Christian Lücke Petra Büttner Holger Thiele Volker Adams Philipp Lurz Fabian Emrich Christian Besler |
| author_facet | Danilo Obradovic Karl‐Philipp Rommel Stephan Blazek Karin Klingel Matthias Gutberlet Christian Lücke Petra Büttner Holger Thiele Volker Adams Philipp Lurz Fabian Emrich Christian Besler |
| author_sort | Danilo Obradovic |
| collection | DOAJ |
| description | Abstract Aims Establishing a diagnosis of inflammatory cardiomyopathy (iCMP) by non‐invasive means remains challenging despite advances in cardiac magnetic resonance imaging. Previous studies suggested the involvement of microRNAs in the pathogenesis of iCMP. We examined the association of a predefined set of circulatory microRNAs with clinical characteristics of iCMP and evaluated their diagnostic performance in suspected iCMP. Methods and results Eighty‐nine patients with clinical suspicion of iCMP were included in the analysis. All patients underwent cardiac catheterization with left ventricular endomyocardial biopsy, echocardiography, and cardiac magnetic resonance imaging applying the Lake Louise criteria (LLC). Plasma levels of miR‐21, miR‐126, miR‐133a, miR‐146b, miR‐155, and miR‐206 were determined using real‐time polymerase chain reaction. Based on immunohistological findings on endomyocardial biopsy, iCMP was diagnosed in 67% of study participants (n = 60). Plasma levels of miR‐155 and miR‐206 were significantly increased in patients with iCMP as compared with patients with dilated cardiomyopathy (P = 0.008 and P = 0.009, respectively). In receiver operating characteristic curve analysis, miR‐155 and miR‐206 demonstrated superior diagnostic performance for iCMP (0.68 and 0.67, respectively) compared with LLC [area under the curve (AUC) 0.60], Troponin T (AUC 0.51), and N‐terminal pro‐brain natriuretic peptide (AUC 0.51). While baseline miR‐155 and miR‐206 plasma levels were predictive for biopsy‐proven iCMP (odds ratio = 2.61, 95% confidence interval = 1.28–5.31, P = 0.008 and odds ratio = 2.65, 95% confidence interval = 1.27–5.52, P = 0.009) on univariate logistic regression analysis, the presence of positive LLC, high baseline C‐reactive protein, or presence of clinical symptoms and signs of viral infection failed to predict iCMP (P > 0.05, respectively). Conclusions The present data suggest that plasma levels of miR‐206 and miR‐155 are potential novel biomarkers for confirming the diagnosis of iCMP. |
| first_indexed | 2024-04-11T04:51:03Z |
| format | Article |
| id | doaj.art-68a54de20c4441b0bc7b4072c0186354 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-11T04:51:03Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-68a54de20c4441b0bc7b4072c01863542022-12-27T03:53:06ZengWileyESC Heart Failure2055-58222021-06-01831850186010.1002/ehf2.13304The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathyDanilo Obradovic0Karl‐Philipp Rommel1Stephan Blazek2Karin Klingel3Matthias Gutberlet4Christian Lücke5Petra Büttner6Holger Thiele7Volker Adams8Philipp Lurz9Fabian Emrich10Christian Besler11Department of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyCardiopathology, Institute for Pathology and Neuropathology University Hospital Tübingen Tübingen GermanyDepartment of Diagnostic and Interventional Radiology Heart Center Leipzig Leipzig GermanyDepartment of Diagnostic and Interventional Radiology Heart Center Leipzig Leipzig GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyLaboratory of Molecular and Experimental Cardiology, Heart Center Dresden Technical University Dresden Dresden GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyDepartment of Cardiothoracic Surgery University Hospital Frankfurt Frankfurt GermanyDepartment of Internal Medicine/Cardiology Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute Strümpellstraße 39 Leipzig 04289 GermanyAbstract Aims Establishing a diagnosis of inflammatory cardiomyopathy (iCMP) by non‐invasive means remains challenging despite advances in cardiac magnetic resonance imaging. Previous studies suggested the involvement of microRNAs in the pathogenesis of iCMP. We examined the association of a predefined set of circulatory microRNAs with clinical characteristics of iCMP and evaluated their diagnostic performance in suspected iCMP. Methods and results Eighty‐nine patients with clinical suspicion of iCMP were included in the analysis. All patients underwent cardiac catheterization with left ventricular endomyocardial biopsy, echocardiography, and cardiac magnetic resonance imaging applying the Lake Louise criteria (LLC). Plasma levels of miR‐21, miR‐126, miR‐133a, miR‐146b, miR‐155, and miR‐206 were determined using real‐time polymerase chain reaction. Based on immunohistological findings on endomyocardial biopsy, iCMP was diagnosed in 67% of study participants (n = 60). Plasma levels of miR‐155 and miR‐206 were significantly increased in patients with iCMP as compared with patients with dilated cardiomyopathy (P = 0.008 and P = 0.009, respectively). In receiver operating characteristic curve analysis, miR‐155 and miR‐206 demonstrated superior diagnostic performance for iCMP (0.68 and 0.67, respectively) compared with LLC [area under the curve (AUC) 0.60], Troponin T (AUC 0.51), and N‐terminal pro‐brain natriuretic peptide (AUC 0.51). While baseline miR‐155 and miR‐206 plasma levels were predictive for biopsy‐proven iCMP (odds ratio = 2.61, 95% confidence interval = 1.28–5.31, P = 0.008 and odds ratio = 2.65, 95% confidence interval = 1.27–5.52, P = 0.009) on univariate logistic regression analysis, the presence of positive LLC, high baseline C‐reactive protein, or presence of clinical symptoms and signs of viral infection failed to predict iCMP (P > 0.05, respectively). Conclusions The present data suggest that plasma levels of miR‐206 and miR‐155 are potential novel biomarkers for confirming the diagnosis of iCMP.https://doi.org/10.1002/ehf2.13304Inflammatory cardiomyopathyDilated cardiomyopathymiRNAEndomyocardial biopsyCardiovascular magnetic resonance imagingLake Louise criteria |
| spellingShingle | Danilo Obradovic Karl‐Philipp Rommel Stephan Blazek Karin Klingel Matthias Gutberlet Christian Lücke Petra Büttner Holger Thiele Volker Adams Philipp Lurz Fabian Emrich Christian Besler The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy ESC Heart Failure Inflammatory cardiomyopathy Dilated cardiomyopathy miRNA Endomyocardial biopsy Cardiovascular magnetic resonance imaging Lake Louise criteria |
| title | The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy |
| title_full | The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy |
| title_fullStr | The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy |
| title_full_unstemmed | The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy |
| title_short | The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy |
| title_sort | potential role of plasma mir 155 and mir 206 as circulatory biomarkers in inflammatory cardiomyopathy |
| topic | Inflammatory cardiomyopathy Dilated cardiomyopathy miRNA Endomyocardial biopsy Cardiovascular magnetic resonance imaging Lake Louise criteria |
| url | https://doi.org/10.1002/ehf2.13304 |
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