Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases
The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate variou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/23/2724 |
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| author | Manuel Castillejos-López Yair Romero Angelica Varela-Ordoñez Edgar Flores-Soto Bianca S. Romero-Martinez Rafael Velázquez-Cruz Joel Armando Vázquez-Pérez Víctor Ruiz Juan C. Gomez-Verjan Nadia A. Rivero-Segura Ángel Camarena Ana Karen Torres-Soria Georgina Gonzalez-Avila Bettina Sommer Héctor Solís-Chagoyán Ruth Jaimez Luz María Torres-Espíndola Arnoldo Aquino-Gálvez |
| author_facet | Manuel Castillejos-López Yair Romero Angelica Varela-Ordoñez Edgar Flores-Soto Bianca S. Romero-Martinez Rafael Velázquez-Cruz Joel Armando Vázquez-Pérez Víctor Ruiz Juan C. Gomez-Verjan Nadia A. Rivero-Segura Ángel Camarena Ana Karen Torres-Soria Georgina Gonzalez-Avila Bettina Sommer Héctor Solís-Chagoyán Ruth Jaimez Luz María Torres-Espíndola Arnoldo Aquino-Gálvez |
| author_sort | Manuel Castillejos-López |
| collection | DOAJ |
| description | The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases. In the present work, we intended to review the functional repercussions of hypoxia in the presence of asthma, chronic obstructive sleep apnea, lung cancer, idiopathic pulmonary fibrosis, obstructive sleep apnea, influenza, and COVID-19 and its repercussions on the circadian cycles. |
| first_indexed | 2024-03-09T01:53:51Z |
| format | Article |
| id | doaj.art-68a663c5a2184d39875d01a86552c0fb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T01:53:51Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-68a663c5a2184d39875d01a86552c0fb2023-12-08T15:13:10ZengMDPI AGCells2073-44092023-11-011223272410.3390/cells12232724Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory DiseasesManuel Castillejos-López0Yair Romero1Angelica Varela-Ordoñez2Edgar Flores-Soto3Bianca S. Romero-Martinez4Rafael Velázquez-Cruz5Joel Armando Vázquez-Pérez6Víctor Ruiz7Juan C. Gomez-Verjan8Nadia A. Rivero-Segura9Ángel Camarena10Ana Karen Torres-Soria11Georgina Gonzalez-Avila12Bettina Sommer13Héctor Solís-Chagoyán14Ruth Jaimez15Luz María Torres-Espíndola16Arnoldo Aquino-Gálvez17Departamento de Epidemiología e Infectología Hospitalaria, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoFacultad de Ciencias, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, MexicoRed MEDICI, Carrera de Médico Cirujano, Facultad de Estudios Superiores de Iztacala Universidad Nacional Autónoma de México, Mexico City 54090, MexicoDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, MexicoDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, MexicoLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, MexicoLaboratorio de Biología Molecular de Enfermedades Emergentes y EPOC, Instituto Nacional de Enferdades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoLaboratorio de Biología Molecular, Departamento de Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoDirección de Investigación, Instituto Nacional de Geriatría (INGER), Mexico City 10200, MexicoDirección de Investigación, Instituto Nacional de Geriatría (INGER), Mexico City 10200, MexicoLaboratorio de Inmunobiología y Genética, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoRed MEDICI, Carrera de Médico Cirujano, Facultad de Estudios Superiores de Iztacala Universidad Nacional Autónoma de México, Mexico City 54090, MexicoLaboratorio de Oncología Biomédica, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoDepartamento de Investigación en Hiperreactividad Bronquial, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoLaboratorio de Neurobiología Cognitiva, Centro de Investigación en Ciencias Cognitivas, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, MexicoLaboratorio de Farmacología, Instituto Nacional de Pediatría (INP), Mexico City 04530, MexicoLaboratorio de Biología Molecular, Departamento de Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, MexicoThe function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases. In the present work, we intended to review the functional repercussions of hypoxia in the presence of asthma, chronic obstructive sleep apnea, lung cancer, idiopathic pulmonary fibrosis, obstructive sleep apnea, influenza, and COVID-19 and its repercussions on the circadian cycles.https://www.mdpi.com/2073-4409/12/23/2724circadian cyclelung diseaseshypoxiagenesidiopathic pulmonary fibrosis |
| spellingShingle | Manuel Castillejos-López Yair Romero Angelica Varela-Ordoñez Edgar Flores-Soto Bianca S. Romero-Martinez Rafael Velázquez-Cruz Joel Armando Vázquez-Pérez Víctor Ruiz Juan C. Gomez-Verjan Nadia A. Rivero-Segura Ángel Camarena Ana Karen Torres-Soria Georgina Gonzalez-Avila Bettina Sommer Héctor Solís-Chagoyán Ruth Jaimez Luz María Torres-Espíndola Arnoldo Aquino-Gálvez Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases Cells circadian cycle lung diseases hypoxia genes idiopathic pulmonary fibrosis |
| title | Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases |
| title_full | Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases |
| title_fullStr | Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases |
| title_full_unstemmed | Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases |
| title_short | Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases |
| title_sort | hypoxia induces alterations in the circadian rhythm in patients with chronic respiratory diseases |
| topic | circadian cycle lung diseases hypoxia genes idiopathic pulmonary fibrosis |
| url | https://www.mdpi.com/2073-4409/12/23/2724 |
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