The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties
Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (<i>Mentha</i> species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/1118 |
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| author | Majid Tafrihi Muhammad Imran Tabussam Tufail Tanweer Aslam Gondal Gianluca Caruso Somesh Sharma Ruchi Sharma Maria Atanassova Lyubomir Atanassov Patrick Valere Tsouh Fokou Raffaele Pezzani |
| author_facet | Majid Tafrihi Muhammad Imran Tabussam Tufail Tanweer Aslam Gondal Gianluca Caruso Somesh Sharma Ruchi Sharma Maria Atanassova Lyubomir Atanassov Patrick Valere Tsouh Fokou Raffaele Pezzani |
| author_sort | Majid Tafrihi |
| collection | DOAJ |
| description | Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (<i>Mentha</i> species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. <i>Mentha</i> species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against <i>Bacillus subtilis</i>, <i>Streptococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants. |
| first_indexed | 2024-03-09T00:42:26Z |
| format | Article |
| id | doaj.art-68a667778f9846058f1af7b47b2371f5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T00:42:26Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-68a667778f9846058f1af7b47b2371f52023-12-11T17:45:00ZengMDPI AGMolecules1420-30492021-02-01264111810.3390/molecules26041118The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant PropertiesMajid Tafrihi0Muhammad Imran1Tabussam Tufail2Tanweer Aslam Gondal3Gianluca Caruso4Somesh Sharma5Ruchi Sharma6Maria Atanassova7Lyubomir Atanassov8Patrick Valere Tsouh Fokou9Raffaele Pezzani10Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar 4741695447, IranUniversity Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore 54600, PakistanUniversity Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore 54600, PakistanSchool of Exercise and Nutrition, Deakin University, Victoria 3125, AustraliaDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici (Naples), ItalySchool of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaSchool of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaScientific Consulting, Chemical Engineering, University of Chemical Technology and Metallurgy, 1734 Sofia, BulgariaSaint Petersburg University, 7/9 Universitetskaya Emb., 199034 St. Petersburg, RussiaDepartment of Biochemistry, Faculty of Science, University of Bamenda, Bamenda BP 39, CameroonPhytotherapy LAB (PhT-LAB), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, 35128 Padova, ItalyMedicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (<i>Mentha</i> species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. <i>Mentha</i> species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against <i>Bacillus subtilis</i>, <i>Streptococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.https://www.mdpi.com/1420-3049/26/4/1118mint<i>Mentha</i>, phytochemicalsessential oilsanticancerantimicrobial |
| spellingShingle | Majid Tafrihi Muhammad Imran Tabussam Tufail Tanweer Aslam Gondal Gianluca Caruso Somesh Sharma Ruchi Sharma Maria Atanassova Lyubomir Atanassov Patrick Valere Tsouh Fokou Raffaele Pezzani The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties Molecules mint <i>Mentha</i>, phytochemicals essential oils anticancer antimicrobial |
| title | The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties |
| title_full | The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties |
| title_fullStr | The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties |
| title_full_unstemmed | The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties |
| title_short | The Wonderful Activities of the Genus <i>Mentha</i>: Not Only Antioxidant Properties |
| title_sort | wonderful activities of the genus i mentha i not only antioxidant properties |
| topic | mint <i>Mentha</i>, phytochemicals essential oils anticancer antimicrobial |
| url | https://www.mdpi.com/1420-3049/26/4/1118 |
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