Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis
Abstract Background: Allergic rhinitis is a common disease which is present in 20% of general population. Major symptoms include sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It seems that tricyclic antidepressants blocking histamine receptors may be used as an effective treatment in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Arak Medical University
2015-04-01
|
| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-2376-en.pdf |
| _version_ | 1830273399150084096 |
|---|---|
| author | Zamani Barsari F Soheili H Jamilian HR Saleh Jafari N Rafiei M Tamizi A |
| author_facet | Zamani Barsari F Soheili H Jamilian HR Saleh Jafari N Rafiei M Tamizi A |
| author_sort | Zamani Barsari F |
| collection | DOAJ |
| description | Abstract
Background: Allergic rhinitis is a common disease which is present in 20% of general population. Major symptoms include sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It seems that tricyclic antidepressants blocking histamine receptors may be used as an effective treatment in allergic rhinitis.
Materials and Methods: In this clinical trial study, 84 patients with allergic rhinitis entered the study and randomly divided into two groups. Patients of 1st group received cetirizine and 2nd group received doxepin for 2 weeks. After 2 weeks patients were evaluated about sneezing, rhinorrhea, nasal congestion, and nasal pruritus.
Results: The results of our study showed that clinical score of patients after 2 weeks was not different in both groups (p=0.261). The only symptom that was affected by the kind of treatment and was significantly different between groups was sneezing (p=0.005).
Conclusion: It seems that there is not much difference in using cetirizine and doxepin in treatment of seasonal allergic rhinitis sympotoms. It is recommended that future studies use TCAs with more potent blocking anti-histamine receptors feature and on more samples. |
| first_indexed | 2024-12-18T23:44:25Z |
| format | Article |
| id | doaj.art-68a6b0cd31854bffacc1806adba8446e |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-18T23:44:25Z |
| publishDate | 2015-04-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-68a6b0cd31854bffacc1806adba8446e2022-12-21T20:47:17ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2015-04-011812431Compare of the effect of doxepin and citerizine in treatment of allergic rhinitisZamani Barsari F0Soheili H1Jamilian HR2Saleh Jafari N3Rafiei M4Tamizi A5Department of ENT, Arak University of Medical Sciences, Arak, IranDepartment of Pediatrics, Arak University of medical sciences, Arak, IranDepartment of Psychiatrics, Arak University of medical sciences, Arak, IranDepartment of ENT, Arak University of Medical Sciences, Arak, IranDepartment of Statistics, Arak University of medical sciences, Arak, IranArak University of medical sciences, Arak, IranAbstract Background: Allergic rhinitis is a common disease which is present in 20% of general population. Major symptoms include sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It seems that tricyclic antidepressants blocking histamine receptors may be used as an effective treatment in allergic rhinitis. Materials and Methods: In this clinical trial study, 84 patients with allergic rhinitis entered the study and randomly divided into two groups. Patients of 1st group received cetirizine and 2nd group received doxepin for 2 weeks. After 2 weeks patients were evaluated about sneezing, rhinorrhea, nasal congestion, and nasal pruritus. Results: The results of our study showed that clinical score of patients after 2 weeks was not different in both groups (p=0.261). The only symptom that was affected by the kind of treatment and was significantly different between groups was sneezing (p=0.005). Conclusion: It seems that there is not much difference in using cetirizine and doxepin in treatment of seasonal allergic rhinitis sympotoms. It is recommended that future studies use TCAs with more potent blocking anti-histamine receptors feature and on more samples.http://amuj.arakmu.ac.ir/article-1-2376-en.pdfAllergic RhinitisDoxepinCetirizineTreatment |
| spellingShingle | Zamani Barsari F Soheili H Jamilian HR Saleh Jafari N Rafiei M Tamizi A Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Allergic Rhinitis Doxepin Cetirizine Treatment |
| title | Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| title_full | Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| title_fullStr | Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| title_full_unstemmed | Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| title_short | Compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| title_sort | compare of the effect of doxepin and citerizine in treatment of allergic rhinitis |
| topic | Allergic Rhinitis Doxepin Cetirizine Treatment |
| url | http://amuj.arakmu.ac.ir/article-1-2376-en.pdf |
| work_keys_str_mv | AT zamanibarsarif compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis AT soheilih compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis AT jamilianhr compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis AT salehjafarin compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis AT rafieim compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis AT tamizia compareoftheeffectofdoxepinandciterizineintreatmentofallergicrhinitis |