Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation
AF is the most common cardiac arrhythmia and has been identified as an independent risk factor for stroke. The European Society of Cardiology guidelines recommend a thromboembolic event risk assessment based on the CHA2DS2-VASc score. However, stroke also occurs in some patients with a low CHA2DS2-V...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2022-06-01
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| Series: | Arrhythmia & Electrophysiology Review |
| Online Access: | https://www.aerjournal.com/articleindex/aer.2022.08 |
| _version_ | 1826933195518509056 |
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| author | Katarzyna Dudzińska-Szczerba Piotr Kułakowski Ilona Michałowska Jakub Baran |
| author_facet | Katarzyna Dudzińska-Szczerba Piotr Kułakowski Ilona Michałowska Jakub Baran |
| author_sort | Katarzyna Dudzińska-Szczerba |
| collection | DOAJ |
| description | AF is the most common cardiac arrhythmia and has been identified as an independent risk factor for stroke. The European Society of Cardiology guidelines recommend a thromboembolic event risk assessment based on the CHA2DS2-VASc score. However, stroke also occurs in some patients with a low CHA2DS2-VASc score. Therefore, it is necessary to find new factors to improve thromboembolic risk stratification in AF patients. Over 90% of embolic strokes are caused by thrombi originating from the left atrial appendage (LAA). Thus, certain anatomical or functional parameters of the LAA could potentially be used to predict cardioembolic stroke. Studies have suggested that some of these factors, such as LAA morphology, number of LAA lobes, LAA dimensions, LAA volume, distance from the LAA ostium to the first bend of LAA, LAA orifice diameter, extent of LAA trabeculations, LAA takeoff, LAA flow velocity and LAA strain rate, are independently associated with a higher risk of stroke in a population of patients with AF and improve the performance of the CHA2DS2-VASc score. However, the results are conflicting and, so far, no new parameter has been added to the CHA2DS2-VASc score. |
| first_indexed | 2024-03-07T17:39:59Z |
| format | Article |
| id | doaj.art-68a70c50e73046fea7c5548efedc6554 |
| institution | Directory Open Access Journal |
| issn | 2050-3369 2050-3377 |
| language | English |
| last_indexed | 2025-02-17T17:28:09Z |
| publishDate | 2022-06-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Arrhythmia & Electrophysiology Review |
| spelling | doaj.art-68a70c50e73046fea7c5548efedc65542024-12-14T16:03:43ZengRadcliffe Medical MediaArrhythmia & Electrophysiology Review2050-33692050-33772022-06-011110.15420/aer.2022.08Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial FibrillationKatarzyna Dudzińska-Szczerba0Piotr Kułakowski1Ilona Michałowska2Jakub Baran3Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, PolandDivision of Clinical Electrophysiology, Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, PolandDepartment of Radiology, Institute of Cardiology, Warsaw, PolandDivision of Clinical Electrophysiology, Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, PolandAF is the most common cardiac arrhythmia and has been identified as an independent risk factor for stroke. The European Society of Cardiology guidelines recommend a thromboembolic event risk assessment based on the CHA2DS2-VASc score. However, stroke also occurs in some patients with a low CHA2DS2-VASc score. Therefore, it is necessary to find new factors to improve thromboembolic risk stratification in AF patients. Over 90% of embolic strokes are caused by thrombi originating from the left atrial appendage (LAA). Thus, certain anatomical or functional parameters of the LAA could potentially be used to predict cardioembolic stroke. Studies have suggested that some of these factors, such as LAA morphology, number of LAA lobes, LAA dimensions, LAA volume, distance from the LAA ostium to the first bend of LAA, LAA orifice diameter, extent of LAA trabeculations, LAA takeoff, LAA flow velocity and LAA strain rate, are independently associated with a higher risk of stroke in a population of patients with AF and improve the performance of the CHA2DS2-VASc score. However, the results are conflicting and, so far, no new parameter has been added to the CHA2DS2-VASc score.https://www.aerjournal.com/articleindex/aer.2022.08 |
| spellingShingle | Katarzyna Dudzińska-Szczerba Piotr Kułakowski Ilona Michałowska Jakub Baran Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation Arrhythmia & Electrophysiology Review |
| title | Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation |
| title_full | Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation |
| title_fullStr | Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation |
| title_full_unstemmed | Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation |
| title_short | Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation |
| title_sort | association between left atrial appendage morphology and function and the risk of ischaemic stroke in patients with atrial fibrillation |
| url | https://www.aerjournal.com/articleindex/aer.2022.08 |
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