Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats
Abstract Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-024-01765-z |
| _version_ | 1827316116492386304 |
|---|---|
| author | Jianlong Liu Qingxin Tian Mingxiao Zhang |
| author_facet | Jianlong Liu Qingxin Tian Mingxiao Zhang |
| author_sort | Jianlong Liu |
| collection | DOAJ |
| description | Abstract Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI + VX765, MI + AG-VX765NGs, MI + PEI-VX765NPs, and MI + AG/PEI-VX765NGs. Results demonstrate that AG/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI + AG/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG/PEI-VX765NGs represent a promising therapeutic approach for MI treatment. |
| first_indexed | 2024-04-24T23:09:15Z |
| format | Article |
| id | doaj.art-68a9bd751d6b4d879ff89903064d87e6 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-24T23:09:15Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-68a9bd751d6b4d879ff89903064d87e62024-03-17T12:19:35ZengBMCEuropean Journal of Medical Research2047-783X2024-03-0129111010.1186/s40001-024-01765-zPreparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in ratsJianlong Liu0Qingxin Tian1Mingxiao Zhang2Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI + VX765, MI + AG-VX765NGs, MI + PEI-VX765NPs, and MI + AG/PEI-VX765NGs. Results demonstrate that AG/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI + AG/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG/PEI-VX765NGs represent a promising therapeutic approach for MI treatment.https://doi.org/10.1186/s40001-024-01765-zMyocardial infarctionSodium alginateNanogelCaspase-1 inhibitor |
| spellingShingle | Jianlong Liu Qingxin Tian Mingxiao Zhang Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats European Journal of Medical Research Myocardial infarction Sodium alginate Nanogel Caspase-1 inhibitor |
| title | Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| title_full | Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| title_fullStr | Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| title_full_unstemmed | Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| title_short | Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| title_sort | preparation of vx765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats |
| topic | Myocardial infarction Sodium alginate Nanogel Caspase-1 inhibitor |
| url | https://doi.org/10.1186/s40001-024-01765-z |
| work_keys_str_mv | AT jianlongliu preparationofvx765sodiumalginatenanogelsandevaluationoftheirtherapeuticeffectvialocalinjectiononmyocardialinfarctioninrats AT qingxintian preparationofvx765sodiumalginatenanogelsandevaluationoftheirtherapeuticeffectvialocalinjectiononmyocardialinfarctioninrats AT mingxiaozhang preparationofvx765sodiumalginatenanogelsandevaluationoftheirtherapeuticeffectvialocalinjectiononmyocardialinfarctioninrats |