(<i>S</i>)-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-Dibenzyl-1-cyclohexyl-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-bis((<i>R</i>)-1-phenylethyl)propane-1,3-diamine

(<i>S</i>)-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-Dibenzyl-1-cyclohexyl-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-bis((<i>R</i>)-1-phenylethyl)propane-1,3-diamine

(<i>S</i>)-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-dibenzyl-1-cyclohexyl-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-bis((<i>R</i>)-1-phenylethyl)propane-1,3-diamine was prepared i...

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Bibliographic Details
Main Authors: Leland Belda, Ángel García-González, Alejandro Manchado, Carlos T. Nieto, Narciso M. Garrido
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molbank
Subjects:
1,3-diamine
chiral auxiliar
chiral lithium amide
organocatalysis
aza-Michael addition
Online Access:https://www.mdpi.com/1422-8599/2023/1/M1544
Description
Summary:(<i>S</i>)-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-dibenzyl-1-cyclohexyl-<i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-bis((<i>R</i>)-1-phenylethyl)propane-1,3-diamine was prepared in good yield by the reduction of the corresponding amide, which was obtained by the addition of a chiral lithium amide to an α,β-unsaturated ester. The target compound was fully characterized by NMR (<sup>1</sup>H and <sup>13</sup>C), high-resolution mass spectrometry and polarimetry.
ISSN:1422-8599

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