Cryptorchidism and puberty
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended norma...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1347435/full |
| _version_ | 1797265538621112320 |
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| author | Wiwat Rodprasert Helena E. Virtanen Jorma Toppari Jorma Toppari Jorma Toppari Jorma Toppari |
| author_facet | Wiwat Rodprasert Helena E. Virtanen Jorma Toppari Jorma Toppari Jorma Toppari Jorma Toppari |
| author_sort | Wiwat Rodprasert |
| collection | DOAJ |
| description | Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys with a history of non-syndromic cryptorchidism—both congenital and acquired cryptorchidism. The review is focused on the timing of puberty, physical changes, testicular growth, and endocrine development during puberty. The available evidence demonstrated that the timing of the onset of puberty in boys with a history of congenital cryptorchidism does not differ from that of non-cryptorchid boys. Hypothalamic–pituitary–gonadal hormone measurements showed an impaired function or fewer Sertoli cells and/or germ cells among boys with a history of cryptorchidism, particularly with a history of bilateral cryptorchidism treated with orchiopexy. Leydig cell function is generally not affected in boys with a history of cryptorchidism. Data on pubertal development among boys with acquired cryptorchidism are lacking; therefore, more research is needed to investigate pubertal progression among such boys. |
| first_indexed | 2024-04-25T00:46:23Z |
| format | Article |
| id | doaj.art-68aaaab58c3d4660904f5e1fa2aa0639 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-25T00:46:23Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-68aaaab58c3d4660904f5e1fa2aa06392024-03-12T04:41:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13474351347435Cryptorchidism and pubertyWiwat Rodprasert0Helena E. Virtanen1Jorma Toppari2Jorma Toppari3Jorma Toppari4Jorma Toppari5Research Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, University of Turku, Turku, FinlandResearch Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, University of Turku, Turku, FinlandResearch Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, University of Turku, Turku, FinlandDepartment of Pediatrics, Turku University Hospital, Turku, FinlandDepartment of Growth and Reproduction, Copenhagen University Hospital—Rigshospitalet, Copenhagen, DenmarkCentre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital—Rigshospitalet, Copenhagen, DenmarkCryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys with a history of non-syndromic cryptorchidism—both congenital and acquired cryptorchidism. The review is focused on the timing of puberty, physical changes, testicular growth, and endocrine development during puberty. The available evidence demonstrated that the timing of the onset of puberty in boys with a history of congenital cryptorchidism does not differ from that of non-cryptorchid boys. Hypothalamic–pituitary–gonadal hormone measurements showed an impaired function or fewer Sertoli cells and/or germ cells among boys with a history of cryptorchidism, particularly with a history of bilateral cryptorchidism treated with orchiopexy. Leydig cell function is generally not affected in boys with a history of cryptorchidism. Data on pubertal development among boys with acquired cryptorchidism are lacking; therefore, more research is needed to investigate pubertal progression among such boys.https://www.frontiersin.org/articles/10.3389/fendo.2024.1347435/fullundescended testisLeydig cellSertoli cellgerm celltesticular sizetestosterone |
| spellingShingle | Wiwat Rodprasert Helena E. Virtanen Jorma Toppari Jorma Toppari Jorma Toppari Jorma Toppari Cryptorchidism and puberty Frontiers in Endocrinology undescended testis Leydig cell Sertoli cell germ cell testicular size testosterone |
| title | Cryptorchidism and puberty |
| title_full | Cryptorchidism and puberty |
| title_fullStr | Cryptorchidism and puberty |
| title_full_unstemmed | Cryptorchidism and puberty |
| title_short | Cryptorchidism and puberty |
| title_sort | cryptorchidism and puberty |
| topic | undescended testis Leydig cell Sertoli cell germ cell testicular size testosterone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1347435/full |
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