Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

Our previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZnSOD, Sod1KO mice) have neuromuscular changes resulting in dramatic accelerated muscle atrophy and weakness that mimics age-related sarcopenia. We have further shown that loss of CuZnSOD targeted to skeletal...

Full description

Bibliographic Details
Main Authors:	Kavithalakshmi Sataranatarajan, Rizwan Qaisar, Carol Davis, Giorgos K. Sakellariou, Aphrodite Vasilaki, Yiqiang Zhang, Yuhong Liu, Shylesh Bhaskaran, Anne McArdle, Malcolm Jackson, Susan V. Brooks, Arlan Richardson, Holly Van Remmen
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231715000361

Similar Items

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia
by: Yu Su, et al.
Published: (2021-10-01)

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness
by: Rizwan Qaisar, et al.
Published: (2019-01-01)

Characterization of Copper(II) and Zinc(II) Complexes of Peptides Mimicking the CuZnSOD Enzyme
by: Enikő Székely, et al.
Published: (2024-02-01)

Accelerated vascular aging in CuZnSOD-deficient mice: impact on EPC function and reparative neovascularization.
by: Jessika Groleau, et al.
Published: (2011-01-01)

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
by: Rizwan Qaisar, et al.
Published: (2018-10-01)

Role of Signaling Molecules in Mitochondrial Stress Response
by: Shauna Hill, et al.
Published: (2018-07-01)

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts
by: Gavin Pharaoh, et al.
Published: (2016-08-01)

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia
by: Hongyang Xu, et al.
Published: (2021-12-01)

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis
by: Shylesh Bhaskaran, et al.
Published: (2023-02-01)

Restoration of Sarcoplasmic Reticulum Ca<sup>2+</sup> ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
by: Rizwan Qaisar, et al.
Published: (2020-12-01)

Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice
by: Steve D. Guzman, et al.
Published: (2022-01-01)

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases
by: Rizwan Qaisar, et al.
Published: (2020-10-01)

Redox responses in skeletal muscle following denervation
by: Mattia Scalabrin, et al.
Published: (2019-09-01)

Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease
by: Hongyang Xu, et al.
Published: (2022-04-01)

Prediction of sarcopenia using a battery of circulating biomarkers
by: Rizwan Qaisar, et al.
Published: (2021-04-01)

Prediction of Sarcopenia Using Multiple Biomarkers of Neuromuscular Junction Degeneration in Chronic Obstructive Pulmonary Disease
by: Asima Karim, et al.
Published: (2021-09-01)

Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia
by: Rojina Ranjit, et al.
Published: (2022-11-01)

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.
by: Ryan T Hamilton, et al.
Published: (2013-01-01)

AAV1.NT‐3 gene therapy in the SOD1KO mouse model of accelerated sarcopenia
by: Lingying Tong, et al.
Published: (2023-10-01)

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
by: Bumsoo Ahn, et al.
Published: (2019-04-01)

Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis
by: Rachel McCormick, et al.
Published: (2016-08-01)

Superoxide Dismutases (SODs) and SOD Mimetics
by: Gloria E. O. Borgstahl, et al.
Published: (2018-11-01)

Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
by: Jacob L. Brown, et al.
Published: (2018-10-01)

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock
by: Charchaflieh J, et al.
Published: (2012-07-01)

Quantum algorithms for simulating quantum systems
by: McArdle, S
Published: (2021)

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
by: Xiaowen Wang, et al.
Published: (2021-04-01)

Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness
by: Agnieszka Czyżowska, et al.
Published: (2023-08-01)

Sod production and the effects of liquid organo-mineral fertilizers and thickness of sod
by: Claudinei Paulo de Lima, et al.

The up side of down : why failing well is the key to success /
by: McArdle, Megan,
Published: (2014)

Liquid urbanisms: Framing the intrinsic fluidity of the urban
by: Rachel McArdle
Published: (2023-01-01)

Chemical biology for parasitology: development of chemical probes for a bromodomain in the parasite Schistosoma mansoni
by: McArdle, DJB
Published: (2023)

CSDP and the development of the ‘Global EU’: The progress of EU autonomy in the shadow of Brexit
by: Scarlett McArdle
Published: (2020-02-01)

Doing and Writing Action Research
by: Karen McArdle
Published: (2009-11-01)

Learning from Physics Experiments with Quantum Computers: Applications in Muon Spectroscopy
by: Sam McArdle
Published: (2021-06-01)

From sufficient health to sufficient responsibility
by: Davies, B, et al.
Published: (2020)

Hospital‐associated sarcopenia, acute sarcopenia, and iatrogenic sarcopenia: Prevention of sarcopenia during hospitalization
by: Hidetaka Wakabayashi
Published: (2023-05-01)

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons
by: Meenakshi Sundaram Kumar, et al.
Published: (2022-12-01)

Side chain liquid crystal polymers /
by: McArdle, C. B.
Published: (1989)

The role of military assistance in the problem of arms control : the Middle East, Latin America, and Africa
by: Kelleher, Catherine McArdle
Published: (2013)

The role of military assistance in the problem of arms control : the Middle East, Latin America, and Africa
by: Kelleher, Catherine McArdle
Published: (2013)