Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool

Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool

Despite the high prevalence of chronic pain as a disease in our society, there is a lack of effective treatment options for patients living with this condition. Gene therapies using recombinant AAVs are a direct method to selectively express genes of interest in target cells with the potential of, i...

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Bibliographic Details
Main Authors: Stephanie Mouchbahani-Constance, Camille Lagard, Justine Schweizer, Isabelle Labonté, Miltiadis Georgiopoulos, Colombe Otis, Manon St-Louis, Eric Troncy, Philippe Sarret, Alfredo Ribeiro-Da-Silva, Jean A. Ouellet, Philippe Séguéla, Marie-Eve Paquet, Reza Sharif-Naeini
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Neurobiology of Pain
Subjects:
Pain
Gene therapy
AAV
DREADD
Sodium channel
Chemogenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X23000077

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