Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders
Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternativ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/12/2742 |
| _version_ | 1797455720633860096 |
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| author | Margarida Alberto Ana Cláudia Paiva-Santos Francisco Veiga Patrícia C. Pires |
| author_facet | Margarida Alberto Ana Cláudia Paiva-Santos Francisco Veiga Patrícia C. Pires |
| author_sort | Margarida Alberto |
| collection | DOAJ |
| description | Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternatives to conventional formulations, with the objective of improving drug bioavailability. The present work aimed to analyze the potential of intranasal nanoparticle administration for the treatment of depression and anxiety, using the analysis of several studies already performed. From the carried-out analysis, it was concluded that the use of nanoparticles allows the drug’s protection from enzymatic degradation, and the modulation of its components allows controlled drug release and enhanced drug permeation. Furthermore, the results of in vivo studies further verified these systems’ potential, with the drug reaching the brain faster and leading to increased bioavailability and, consequently, therapeutic effect. Hence, in general, the intranasal administration of nanoparticles leads to a faster onset of action, with increased and prolonged brain drug concentrations and, consequently, therapeutic effects, presenting high potential as an alternative to the currently available therapies for the treatment of depression and anxiety. |
| first_indexed | 2024-03-09T15:58:23Z |
| format | Article |
| id | doaj.art-68b045f529d04735a1f86dd33ae433ee |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:23Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-68b045f529d04735a1f86dd33ae433ee2023-11-24T17:21:15ZengMDPI AGPharmaceutics1999-49232022-12-011412274210.3390/pharmaceutics14122742Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety DisordersMargarida Alberto0Ana Cláudia Paiva-Santos1Francisco Veiga2Patrícia C. Pires3Faculty of Pharmacy, University of Coimbra (FFUC), Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra (FFUC), Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra (FFUC), Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra (FFUC), Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalIntranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternatives to conventional formulations, with the objective of improving drug bioavailability. The present work aimed to analyze the potential of intranasal nanoparticle administration for the treatment of depression and anxiety, using the analysis of several studies already performed. From the carried-out analysis, it was concluded that the use of nanoparticles allows the drug’s protection from enzymatic degradation, and the modulation of its components allows controlled drug release and enhanced drug permeation. Furthermore, the results of in vivo studies further verified these systems’ potential, with the drug reaching the brain faster and leading to increased bioavailability and, consequently, therapeutic effect. Hence, in general, the intranasal administration of nanoparticles leads to a faster onset of action, with increased and prolonged brain drug concentrations and, consequently, therapeutic effects, presenting high potential as an alternative to the currently available therapies for the treatment of depression and anxiety.https://www.mdpi.com/1999-4923/14/12/2742anxietydepressionintranasalnose-to-brainnanoparticles |
| spellingShingle | Margarida Alberto Ana Cláudia Paiva-Santos Francisco Veiga Patrícia C. Pires Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders Pharmaceutics anxiety depression intranasal nose-to-brain nanoparticles |
| title | Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders |
| title_full | Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders |
| title_fullStr | Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders |
| title_full_unstemmed | Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders |
| title_short | Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders |
| title_sort | lipid and polymeric nanoparticles successful strategies for nose to brain drug delivery in the treatment of depression and anxiety disorders |
| topic | anxiety depression intranasal nose-to-brain nanoparticles |
| url | https://www.mdpi.com/1999-4923/14/12/2742 |
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