Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study
ABSTRACT BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2024-02-01
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802024000400201&tlng=en |
| _version_ | 1797294001587486720 |
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| author | Érica Cristina Vieira Milena Soriano Marcolino Antônio Carlos Martins Guedes Mônica Maria Moreira Delgado Maciel Wandilza Fátima dos Santos Luciana Consoli Fernandes Pimentel Paulo Rodrigues Gomes Anita Bressan Kátia de Paula Farah Marcelo Grossi Araújo |
| author_facet | Érica Cristina Vieira Milena Soriano Marcolino Antônio Carlos Martins Guedes Mônica Maria Moreira Delgado Maciel Wandilza Fátima dos Santos Luciana Consoli Fernandes Pimentel Paulo Rodrigues Gomes Anita Bressan Kátia de Paula Farah Marcelo Grossi Araújo |
| author_sort | Érica Cristina Vieira |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients (RTR). OBJECTIVES: To evaluate the frequency of skin diseases in RTR and patients with CKD receiving conservative treatment. DESIGN AND SETTING: This observational cross-sectional study recruited consecutive patients with CKD and RTR from a nephrology clinic at a teaching hospital in Brazil between 2015 and 2020. METHODS: Quantitative, descriptive, and analytical approaches were used. The sample was selected based on convenience sampling. Data were collected from dermatological visits and participants’ medical records. RESULTS: Overall, 308 participants were included: 206 RTR (66.9%, median age: 48 years, interquartile range [IQR] 38.0–56.0, 63.6% men) and 102 patients with CKD (33.1%, median age: 61.0 years, IQR 50.0–71.2, 48% men). The frequency of infectious skin diseases (39.3% vs. 21.6% P = 0.002) were higher in RTR than in patients with CKD. Neoplastic skin lesions were present in nine (4.4%) RTR and in only one (1.0%) patient with CKD. Among the RTR, the ratio of basal cell carcinoma to squamous cell carcinoma was 2:1. CONCLUSIONS: This study revealed that an increased frequency of infectious skin diseases may be expected in patients who have undergone kidney transplantation. Among skin cancers, BCC is more frequently observed in RTR, especially in those using azathioprine. |
| first_indexed | 2024-03-07T21:23:55Z |
| format | Article |
| id | doaj.art-68b0a02b56d246e283b7a4ad5ffac8db |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-03-07T21:23:55Z |
| publishDate | 2024-02-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-68b0a02b56d246e283b7a4ad5ffac8db2024-02-27T07:39:04ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602024-02-01142410.1590/1516-3180.2023.0148.r1.29112023Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional studyÉrica Cristina Vieirahttps://orcid.org/0000-0003-2188-1225Milena Soriano Marcolinohttps://orcid.org/0000-0003-4278-3771Antônio Carlos Martins Guedeshttps://orcid.org/0000-0001-5856-6793Mônica Maria Moreira Delgado Macielhttps://orcid.org/0000-0002-3884-9507Wandilza Fátima dos Santoshttps://orcid.org/0000-0001-6569-5374Luciana Consoli Fernandes Pimentelhttps://orcid.org/0000-0001-5066-8138Paulo Rodrigues Gomeshttps://orcid.org/0000-0002-7949-1812Anita Bressanhttps://orcid.org/0000-0002-6289-536XKátia de Paula Farahhttps://orcid.org/0000-0002-8978-4512Marcelo Grossi Araújohttps://orcid.org/0000-0002-1483-3818ABSTRACT BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients (RTR). OBJECTIVES: To evaluate the frequency of skin diseases in RTR and patients with CKD receiving conservative treatment. DESIGN AND SETTING: This observational cross-sectional study recruited consecutive patients with CKD and RTR from a nephrology clinic at a teaching hospital in Brazil between 2015 and 2020. METHODS: Quantitative, descriptive, and analytical approaches were used. The sample was selected based on convenience sampling. Data were collected from dermatological visits and participants’ medical records. RESULTS: Overall, 308 participants were included: 206 RTR (66.9%, median age: 48 years, interquartile range [IQR] 38.0–56.0, 63.6% men) and 102 patients with CKD (33.1%, median age: 61.0 years, IQR 50.0–71.2, 48% men). The frequency of infectious skin diseases (39.3% vs. 21.6% P = 0.002) were higher in RTR than in patients with CKD. Neoplastic skin lesions were present in nine (4.4%) RTR and in only one (1.0%) patient with CKD. Among the RTR, the ratio of basal cell carcinoma to squamous cell carcinoma was 2:1. CONCLUSIONS: This study revealed that an increased frequency of infectious skin diseases may be expected in patients who have undergone kidney transplantation. Among skin cancers, BCC is more frequently observed in RTR, especially in those using azathioprine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802024000400201&tlng=enSkin diseasesKidney transplantationChronic renal insufficiencyImmunosuppressive agentsBasal cell carcinomaSquamous cell carcinomaDermatosisNon-melanoma skin cancerRenal transplantImmunosupressionKidney failure |
| spellingShingle | Érica Cristina Vieira Milena Soriano Marcolino Antônio Carlos Martins Guedes Mônica Maria Moreira Delgado Maciel Wandilza Fátima dos Santos Luciana Consoli Fernandes Pimentel Paulo Rodrigues Gomes Anita Bressan Kátia de Paula Farah Marcelo Grossi Araújo Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study São Paulo Medical Journal Skin diseases Kidney transplantation Chronic renal insufficiency Immunosuppressive agents Basal cell carcinoma Squamous cell carcinoma Dermatosis Non-melanoma skin cancer Renal transplant Immunosupression Kidney failure |
| title | Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study |
| title_full | Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study |
| title_fullStr | Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study |
| title_full_unstemmed | Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study |
| title_short | Frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center: a cross-sectional study |
| title_sort | frequency of skin diseases in renal transplant recipients and patients with chronic kidney disease in a tertiary center a cross sectional study |
| topic | Skin diseases Kidney transplantation Chronic renal insufficiency Immunosuppressive agents Basal cell carcinoma Squamous cell carcinoma Dermatosis Non-melanoma skin cancer Renal transplant Immunosupression Kidney failure |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802024000400201&tlng=en |
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