Update of the treatment of nosocomial pneumonia in the ICU
Abstract In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), in the event of a patient with such infections, empirical antibi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Critical Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13054-020-03091-2 |
| _version_ | 1819225637072666624 |
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| author | Rafael Zaragoza Pablo Vidal-Cortés Gerardo Aguilar Marcio Borges Emili Diaz Ricard Ferrer Emilio Maseda Mercedes Nieto Francisco Xavier Nuvials Paula Ramirez Alejandro Rodriguez Cruz Soriano Javier Veganzones Ignacio Martín-Loeches |
| author_facet | Rafael Zaragoza Pablo Vidal-Cortés Gerardo Aguilar Marcio Borges Emili Diaz Ricard Ferrer Emilio Maseda Mercedes Nieto Francisco Xavier Nuvials Paula Ramirez Alejandro Rodriguez Cruz Soriano Javier Veganzones Ignacio Martín-Loeches |
| author_sort | Rafael Zaragoza |
| collection | DOAJ |
| description | Abstract In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), in the event of a patient with such infections, empirical antibiotic treatment must be appropriate and administered as early as possible. The aim of this manuscript is to update treatment protocols by reviewing recently published studies on the treatment of nosocomial pneumonia in the critically ill patients that require invasive respiratory support and patients with HAP from hospital wards that require invasive mechanical ventilation. An interdisciplinary group of experts, comprising specialists in anaesthesia and resuscitation and in intensive care medicine, updated the epidemiology and antimicrobial resistance and established clinical management priorities based on patients’ risk factors. Implementation of rapid diagnostic microbiological techniques available and the new antibiotics recently added to the therapeutic arsenal has been reviewed and updated. After analysis of the categories outlined, some recommendations were suggested, and an algorithm to update empirical and targeted treatment in critically ill patients has also been designed. These aspects are key to improve VAP outcomes because of the severity of patients and possible acquisition of multidrug-resistant organisms (MDROs). |
| first_indexed | 2024-12-23T10:12:45Z |
| format | Article |
| id | doaj.art-68b0edd20073481d994ed7857178b0f6 |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-23T10:12:45Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-68b0edd20073481d994ed7857178b0f62022-12-21T17:50:54ZengBMCCritical Care1364-85352020-06-0124111310.1186/s13054-020-03091-2Update of the treatment of nosocomial pneumonia in the ICURafael Zaragoza0Pablo Vidal-Cortés1Gerardo Aguilar2Marcio Borges3Emili Diaz4Ricard Ferrer5Emilio Maseda6Mercedes Nieto7Francisco Xavier Nuvials8Paula Ramirez9Alejandro Rodriguez10Cruz Soriano11Javier Veganzones12Ignacio Martín-Loeches13Critical Care Department, Hospital Universitario Dr. PesetICU, Hospital Universitario OurenseSICU, Hospital Clínico Universitario ValenciaFundación MicelliumDepartment of Medicine, Universitat Autònoma de Barcelona (UAB)ICU, Hospital Vall d’HebrónFundación MicelliumICU, Hospital Clínico Universitario San CarlosICU, Hospital Vall d’HebrónICU, Hospital Universitari I Politecnic La FeICU, Hospital Universitari Joan XXIIIICU, Hospital Universitario Ramón y CajalSICU, Hospital Universitario La PazICU, Trinity Centre for Health Science HRB-Wellcome Trust, St James’s HospitalAbstract In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), in the event of a patient with such infections, empirical antibiotic treatment must be appropriate and administered as early as possible. The aim of this manuscript is to update treatment protocols by reviewing recently published studies on the treatment of nosocomial pneumonia in the critically ill patients that require invasive respiratory support and patients with HAP from hospital wards that require invasive mechanical ventilation. An interdisciplinary group of experts, comprising specialists in anaesthesia and resuscitation and in intensive care medicine, updated the epidemiology and antimicrobial resistance and established clinical management priorities based on patients’ risk factors. Implementation of rapid diagnostic microbiological techniques available and the new antibiotics recently added to the therapeutic arsenal has been reviewed and updated. After analysis of the categories outlined, some recommendations were suggested, and an algorithm to update empirical and targeted treatment in critically ill patients has also been designed. These aspects are key to improve VAP outcomes because of the severity of patients and possible acquisition of multidrug-resistant organisms (MDROs).http://link.springer.com/article/10.1186/s13054-020-03091-2HAPVAPNosocomial pneumoniaCeftolozane-tazobactamCeftazidime-avibactamPseudomonas aeruginosa |
| spellingShingle | Rafael Zaragoza Pablo Vidal-Cortés Gerardo Aguilar Marcio Borges Emili Diaz Ricard Ferrer Emilio Maseda Mercedes Nieto Francisco Xavier Nuvials Paula Ramirez Alejandro Rodriguez Cruz Soriano Javier Veganzones Ignacio Martín-Loeches Update of the treatment of nosocomial pneumonia in the ICU Critical Care HAP VAP Nosocomial pneumonia Ceftolozane-tazobactam Ceftazidime-avibactam Pseudomonas aeruginosa |
| title | Update of the treatment of nosocomial pneumonia in the ICU |
| title_full | Update of the treatment of nosocomial pneumonia in the ICU |
| title_fullStr | Update of the treatment of nosocomial pneumonia in the ICU |
| title_full_unstemmed | Update of the treatment of nosocomial pneumonia in the ICU |
| title_short | Update of the treatment of nosocomial pneumonia in the ICU |
| title_sort | update of the treatment of nosocomial pneumonia in the icu |
| topic | HAP VAP Nosocomial pneumonia Ceftolozane-tazobactam Ceftazidime-avibactam Pseudomonas aeruginosa |
| url | http://link.springer.com/article/10.1186/s13054-020-03091-2 |
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