Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer
Oncolytic viruses (OVs), without harming normal tissues, selectively infect and replicate within tumor cells, to release immune molecules and tumor antigens, achieving immune-mediated destruction of tumors and making them one of the most promising immunotherapies for cancer. Many clinical studies ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5291 |
| _version_ | 1797632066276294656 |
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| author | Zhan Wang Peng Sun Zhiyong Li Shaowen Xiao |
| author_facet | Zhan Wang Peng Sun Zhiyong Li Shaowen Xiao |
| author_sort | Zhan Wang |
| collection | DOAJ |
| description | Oncolytic viruses (OVs), without harming normal tissues, selectively infect and replicate within tumor cells, to release immune molecules and tumor antigens, achieving immune-mediated destruction of tumors and making them one of the most promising immunotherapies for cancer. Many clinical studies have demonstrated that OVs can provide clinical benefits for patients with different types of tumors, at various stages, including metastatic and previously untreatable cases. When OVs are used in combination with chemotherapy, radiotherapy, immunotherapy, and other treatments, they can synergistically enhance the therapeutic effects. The concept of oncolytic virotherapy (OVT) was proposed in the early 20th century. With advancements in genetic engineering, genetically modified viruses can further enhance the efficacy of cancer immunotherapy. In recent years, global research on OV treatment of malignant tumors has increased dramatically. This article comprehensively reviews the findings from relevant research and clinical trials, providing an overview of the development of OVT and its application in the clinical treatment of head and neck cancer. The aim is to offer insights for future clinical and fundamental research on OVT. |
| first_indexed | 2024-03-11T11:32:38Z |
| format | Article |
| id | doaj.art-68b14228cf9c4a64a0ddb954ce0de645 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:38Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-68b14228cf9c4a64a0ddb954ce0de6452023-11-10T15:00:32ZengMDPI AGCancers2072-66942023-11-011521529110.3390/cancers15215291Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck CancerZhan Wang0Peng Sun1Zhiyong Li2Shaowen Xiao3Department of Stomatology, Wenzhou Medical University Renji College, Wenzhou 325000, ChinaSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325000, ChinaSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325000, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, ChinaOncolytic viruses (OVs), without harming normal tissues, selectively infect and replicate within tumor cells, to release immune molecules and tumor antigens, achieving immune-mediated destruction of tumors and making them one of the most promising immunotherapies for cancer. Many clinical studies have demonstrated that OVs can provide clinical benefits for patients with different types of tumors, at various stages, including metastatic and previously untreatable cases. When OVs are used in combination with chemotherapy, radiotherapy, immunotherapy, and other treatments, they can synergistically enhance the therapeutic effects. The concept of oncolytic virotherapy (OVT) was proposed in the early 20th century. With advancements in genetic engineering, genetically modified viruses can further enhance the efficacy of cancer immunotherapy. In recent years, global research on OV treatment of malignant tumors has increased dramatically. This article comprehensively reviews the findings from relevant research and clinical trials, providing an overview of the development of OVT and its application in the clinical treatment of head and neck cancer. The aim is to offer insights for future clinical and fundamental research on OVT.https://www.mdpi.com/2072-6694/15/21/5291head and neck canceroncolytic virusesclinical trialsimmunotherapy |
| spellingShingle | Zhan Wang Peng Sun Zhiyong Li Shaowen Xiao Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer Cancers head and neck cancer oncolytic viruses clinical trials immunotherapy |
| title | Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer |
| title_full | Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer |
| title_fullStr | Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer |
| title_full_unstemmed | Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer |
| title_short | Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer |
| title_sort | clinical advances and future directions of oncolytic virotherapy for head and neck cancer |
| topic | head and neck cancer oncolytic viruses clinical trials immunotherapy |
| url | https://www.mdpi.com/2072-6694/15/21/5291 |
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