Molecular Mechanisms and Emerging Therapeutics for Osteoporosis
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis could become a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/20/7623 |
| _version_ | 1797550932496482304 |
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| author | Ji-Yoon Noh Young Yang Haiyoung Jung |
| author_facet | Ji-Yoon Noh Young Yang Haiyoung Jung |
| author_sort | Ji-Yoon Noh |
| collection | DOAJ |
| description | Osteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis could become a global challenge with an impact on the quality of life of the affected individuals. Osteoporosis can be defined as a condition characterized by low bone density and increased risk of fractures due to the deterioration of the bone architecture. Thus, the major goal of treatment is to reduce the risk for fractures. There are several treatment options, mostly medications that can control disease progression in risk groups, such as postmenopausal women and elderly men. Recent studies on the basic molecular mechanisms and clinical implications of osteoporosis have identified novel therapeutic targets. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for osteoporosis management in the future. Here, we review the etiology of osteoporosis and the molecular mechanism of bone remodeling, present current pharmacological options, and discuss emerging therapies targeting novel mechanisms, investigational treatments, and new promising therapeutic approaches. |
| first_indexed | 2024-03-10T15:36:28Z |
| format | Article |
| id | doaj.art-68b33883406e4b18957d9b3d1e9d22ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:36:28Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-68b33883406e4b18957d9b3d1e9d22ff2023-11-20T17:10:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120762310.3390/ijms21207623Molecular Mechanisms and Emerging Therapeutics for OsteoporosisJi-Yoon Noh0Young Yang1Haiyoung Jung2Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, KoreaResearch Institute of Women’s Health, Sookmyung Women’s University, 100 Cheongparo47gil, Yongsan-Gu, Seoul 04310, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, KoreaOsteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis could become a global challenge with an impact on the quality of life of the affected individuals. Osteoporosis can be defined as a condition characterized by low bone density and increased risk of fractures due to the deterioration of the bone architecture. Thus, the major goal of treatment is to reduce the risk for fractures. There are several treatment options, mostly medications that can control disease progression in risk groups, such as postmenopausal women and elderly men. Recent studies on the basic molecular mechanisms and clinical implications of osteoporosis have identified novel therapeutic targets. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for osteoporosis management in the future. Here, we review the etiology of osteoporosis and the molecular mechanism of bone remodeling, present current pharmacological options, and discuss emerging therapies targeting novel mechanisms, investigational treatments, and new promising therapeutic approaches.https://www.mdpi.com/1422-0067/21/20/7623osteoporosisfracturemedicationmolecular mechanismnovel approach |
| spellingShingle | Ji-Yoon Noh Young Yang Haiyoung Jung Molecular Mechanisms and Emerging Therapeutics for Osteoporosis International Journal of Molecular Sciences osteoporosis fracture medication molecular mechanism novel approach |
| title | Molecular Mechanisms and Emerging Therapeutics for Osteoporosis |
| title_full | Molecular Mechanisms and Emerging Therapeutics for Osteoporosis |
| title_fullStr | Molecular Mechanisms and Emerging Therapeutics for Osteoporosis |
| title_full_unstemmed | Molecular Mechanisms and Emerging Therapeutics for Osteoporosis |
| title_short | Molecular Mechanisms and Emerging Therapeutics for Osteoporosis |
| title_sort | molecular mechanisms and emerging therapeutics for osteoporosis |
| topic | osteoporosis fracture medication molecular mechanism novel approach |
| url | https://www.mdpi.com/1422-0067/21/20/7623 |
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