Advances in neoteric modular tissue engineering strategies for regenerative dentistry
Regenerative and translational dentistry marks a shift in the paradigm of endodontic and periodontic therapy from simple pulp capping and root planning to dental tissue reconstruction. The construction of complex soft and hard tissue-based dental structures and whole bioengineered tooth aims to repa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217922000752 |
| _version_ | 1828097801377021952 |
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| author | Kaushita Banerjee Janani Radhakrishnan Niraikulam Ayyadurai Ponesakki Ganesan Numbi Ramudu Kamini |
| author_facet | Kaushita Banerjee Janani Radhakrishnan Niraikulam Ayyadurai Ponesakki Ganesan Numbi Ramudu Kamini |
| author_sort | Kaushita Banerjee |
| collection | DOAJ |
| description | Regenerative and translational dentistry marks a shift in the paradigm of endodontic and periodontic therapy from simple pulp capping and root planning to dental tissue reconstruction. The construction of complex soft and hard tissue-based dental structures and whole bioengineered tooth aims to repair and refurbish tissues partly or wholly. Anatomic complexity of tooth challenges to engineering native tissue-mimetic microenvironment with the reinstallation of angio/vasculogenesis and innervation. Dental biomaterials and regenerative engineering have exponentially advanced diverse therapeutic strategies, categorized into scaffold-based and scaffold-free. Scaffold-based stratagems use cells, signals, biodegradable and mechanically stable polymeric scaffolds to address specific clinical requirements and achieve cell retention with high survival. Restricted scientific ambiguity, scalability, costs, lack of federal approval, and technology transfer from ‘lab bench to dental chair’ necessitates alternates complying with the regulatory framework and reproducible clinical outcomes. Dental stem cells/cells intrinsically secrete cytokines and matrix molecules, balance local inflammation, and form exclusive tissue analogous constructs devoid of exogenous biomaterials as scaffold-free strategies. Scaffold-free tissue engineering explores prefabricated multicellular building blocks: cell sheets, spheroids, exosomes, hypoxic- and heat shock protein-based and, more lately, tissue strands as the newest addition. The modular bottom-up strategy mimics the tissue microenvironment through the self-assembly of monodispersed cells into three-dimensional (3D) tissue with cell–cell/matrix communications. This review compiles the neoteric scaffold-less strategies exploited for endodontic and periodontic regeneration, emphasizing clinical translation and commercialization of some scaffold-less cell-based systems. Additionally, the synergy between the endo-perio continuum in deferred oral healing and the cutting-edge 3D bio fabrication strategy of scaffold-free systems has been highlighted. |
| first_indexed | 2024-04-11T07:51:35Z |
| format | Article |
| id | doaj.art-68b389817b894ecaa95e54042f4532bf |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-04-11T07:51:35Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-68b389817b894ecaa95e54042f4532bf2022-12-22T04:36:03ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792022-12-0174100491Advances in neoteric modular tissue engineering strategies for regenerative dentistryKaushita Banerjee0Janani Radhakrishnan1Niraikulam Ayyadurai2Ponesakki Ganesan3Numbi Ramudu Kamini4Department of Biochemistry and Biotechnology, CSIR – Central Leather Research Institute, Chennai, Tamil Nadu, 600020, IndiaDepartment of Biochemistry and Biotechnology, CSIR – Central Leather Research Institute, Chennai, Tamil Nadu, 600020, IndiaDepartment of Biochemistry and Biotechnology, CSIR – Central Leather Research Institute, Chennai, Tamil Nadu, 600020, IndiaDepartment of Biochemistry and Biotechnology, CSIR – Central Leather Research Institute, Chennai, Tamil Nadu, 600020, IndiaCorresponding author. Fax: +91 044 2491 1589.; Department of Biochemistry and Biotechnology, CSIR – Central Leather Research Institute, Chennai, Tamil Nadu, 600020, IndiaRegenerative and translational dentistry marks a shift in the paradigm of endodontic and periodontic therapy from simple pulp capping and root planning to dental tissue reconstruction. The construction of complex soft and hard tissue-based dental structures and whole bioengineered tooth aims to repair and refurbish tissues partly or wholly. Anatomic complexity of tooth challenges to engineering native tissue-mimetic microenvironment with the reinstallation of angio/vasculogenesis and innervation. Dental biomaterials and regenerative engineering have exponentially advanced diverse therapeutic strategies, categorized into scaffold-based and scaffold-free. Scaffold-based stratagems use cells, signals, biodegradable and mechanically stable polymeric scaffolds to address specific clinical requirements and achieve cell retention with high survival. Restricted scientific ambiguity, scalability, costs, lack of federal approval, and technology transfer from ‘lab bench to dental chair’ necessitates alternates complying with the regulatory framework and reproducible clinical outcomes. Dental stem cells/cells intrinsically secrete cytokines and matrix molecules, balance local inflammation, and form exclusive tissue analogous constructs devoid of exogenous biomaterials as scaffold-free strategies. Scaffold-free tissue engineering explores prefabricated multicellular building blocks: cell sheets, spheroids, exosomes, hypoxic- and heat shock protein-based and, more lately, tissue strands as the newest addition. The modular bottom-up strategy mimics the tissue microenvironment through the self-assembly of monodispersed cells into three-dimensional (3D) tissue with cell–cell/matrix communications. This review compiles the neoteric scaffold-less strategies exploited for endodontic and periodontic regeneration, emphasizing clinical translation and commercialization of some scaffold-less cell-based systems. Additionally, the synergy between the endo-perio continuum in deferred oral healing and the cutting-edge 3D bio fabrication strategy of scaffold-free systems has been highlighted.http://www.sciencedirect.com/science/article/pii/S2468217922000752Regenerative dentistryScaffold-free strategiesDental pulpPeriodontium3D bio-fabrication |
| spellingShingle | Kaushita Banerjee Janani Radhakrishnan Niraikulam Ayyadurai Ponesakki Ganesan Numbi Ramudu Kamini Advances in neoteric modular tissue engineering strategies for regenerative dentistry Journal of Science: Advanced Materials and Devices Regenerative dentistry Scaffold-free strategies Dental pulp Periodontium 3D bio-fabrication |
| title | Advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| title_full | Advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| title_fullStr | Advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| title_full_unstemmed | Advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| title_short | Advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| title_sort | advances in neoteric modular tissue engineering strategies for regenerative dentistry |
| topic | Regenerative dentistry Scaffold-free strategies Dental pulp Periodontium 3D bio-fabrication |
| url | http://www.sciencedirect.com/science/article/pii/S2468217922000752 |
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