Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome
Objective FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). Methods A total of 344 recent small subcortical infarct (RSSI) pa...
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PeerJ Inc.
2022-03-01
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| Online Access: | https://peerj.com/articles/13101.pdf |
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| author | Zhongnan Hao Shaonan Yang Ruihua Yin Jin Wei Yuan Wang Xudong Pan Aijun Ma |
| author_facet | Zhongnan Hao Shaonan Yang Ruihua Yin Jin Wei Yuan Wang Xudong Pan Aijun Ma |
| author_sort | Zhongnan Hao |
| collection | DOAJ |
| description | Objective FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). Methods A total of 344 recent small subcortical infarct (RSSI) patients and 265 healthy controls were included in this study. The difference in the FAM19A5 level between the two groups was compared and the correlation between FAM19A5 and cerebral infarction volume was analyzed. Also, the association between FAM19A5 and the total magnetic resonance imaging (MRI) burden with its imaging characteristics was explored. Moreover, the correspondence of FAM19A5 with the outcome was assessed via Δ National Institutes of Health Stroke Scale score (NIHSS) and the percentage of NIHSS improvement. Results FAM19A5 was highly expressed in the RSSI group (P = 0.023), showing a positive correlation with cerebral infarction volume (P < 0.01). It was positively correlated with total MRI cSVD burden (P < 0.001) and reflected the severity of white matter hyperintensity (WMH) (P < 0.01) and enlarged perivascular space (EPVS) (P < 0.01), but did not show any association with cerebral microbleed (CMB) and lacune. Moreover, FAM19A5 suggested a larger Δ NIHSS (P = 0.021) and NIHSS improvement percentage (P = 0.007). Conclusion Serum FAM19A5 was increased in RSSI and positively correlated with the infarct volume. It also reflects the total MRI burden of cSVD, of which the imaging characteristics are positively correlated with WMH and EPVS. In addition, higher FAM19A5 levels reflect better outcomes in RSSI patients. |
| first_indexed | 2024-03-09T06:40:14Z |
| format | Article |
| id | doaj.art-68b50d73ee2e49af9bbd065be8d3cb57 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:40:14Z |
| publishDate | 2022-03-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-68b50d73ee2e49af9bbd065be8d3cb572023-12-03T10:51:40ZengPeerJ Inc.PeerJ2167-83592022-03-0110e1310110.7717/peerj.13101Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcomeZhongnan Hao0Shaonan Yang1Ruihua Yin2Jin Wei3Yuan Wang4Xudong Pan5Aijun Ma6The Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao, ChinaObjective FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). Methods A total of 344 recent small subcortical infarct (RSSI) patients and 265 healthy controls were included in this study. The difference in the FAM19A5 level between the two groups was compared and the correlation between FAM19A5 and cerebral infarction volume was analyzed. Also, the association between FAM19A5 and the total magnetic resonance imaging (MRI) burden with its imaging characteristics was explored. Moreover, the correspondence of FAM19A5 with the outcome was assessed via Δ National Institutes of Health Stroke Scale score (NIHSS) and the percentage of NIHSS improvement. Results FAM19A5 was highly expressed in the RSSI group (P = 0.023), showing a positive correlation with cerebral infarction volume (P < 0.01). It was positively correlated with total MRI cSVD burden (P < 0.001) and reflected the severity of white matter hyperintensity (WMH) (P < 0.01) and enlarged perivascular space (EPVS) (P < 0.01), but did not show any association with cerebral microbleed (CMB) and lacune. Moreover, FAM19A5 suggested a larger Δ NIHSS (P = 0.021) and NIHSS improvement percentage (P = 0.007). Conclusion Serum FAM19A5 was increased in RSSI and positively correlated with the infarct volume. It also reflects the total MRI burden of cSVD, of which the imaging characteristics are positively correlated with WMH and EPVS. In addition, higher FAM19A5 levels reflect better outcomes in RSSI patients.https://peerj.com/articles/13101.pdfFAM19A5Cerebral small vessel diseaseRecent small subcortical infarctWhite matter hyperintensityEnlarged perivascular space |
| spellingShingle | Zhongnan Hao Shaonan Yang Ruihua Yin Jin Wei Yuan Wang Xudong Pan Aijun Ma Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome PeerJ FAM19A5 Cerebral small vessel disease Recent small subcortical infarct White matter hyperintensity Enlarged perivascular space |
| title | Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome |
| title_full | Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome |
| title_fullStr | Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome |
| title_full_unstemmed | Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome |
| title_short | Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome |
| title_sort | increased level of fam19a5 is associated with cerebral small vessel disease and leads to a better outcome |
| topic | FAM19A5 Cerebral small vessel disease Recent small subcortical infarct White matter hyperintensity Enlarged perivascular space |
| url | https://peerj.com/articles/13101.pdf |
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