Mapping the Time Line of Development in Each Layer of Human Foetal Retina
Introduction: There is need to elucidate the histological developmental stages of various layers of retina, to understand the process better and provide clinically significant insights. Aim: To study the details and chronology of in utero development of different layers of retina. Materials and...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7372/14936_CE(RA1)_F(T)_PF1(Vsu_Om)_PFA(NC_AK)_PF2(PAG).pdf |
| _version_ | 1818133884655632384 |
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| author | Tulika Gupta Kanchan Kapoor Daisy Sahni Balbir Singh |
| author_facet | Tulika Gupta Kanchan Kapoor Daisy Sahni Balbir Singh |
| author_sort | Tulika Gupta |
| collection | DOAJ |
| description | Introduction: There is need to elucidate the histological
developmental stages of various layers of retina, to understand
the process better and provide clinically significant insights.
Aim: To study the details and chronology of in utero development
of different layers of retina.
Materials and Methods: To study time of appearance, differentiation and organization of all layers of central retina in different
gestational age groups. Retina was studied histologically in 27
foetuses from18th to 34th weeks of gestation.
Results: We found the period of mid gestation (19th -21st week
of gestation) to be the defining time for retinal layers: The
bruch’s membrane was fully formed at 20th week of gestation;
the photoreceptor layer became well defined at 21st week of
gestation; both the nuclear layers and both the plexiform layers
and the ganglion cell layer became distinct at 19th week of
gestation. Before the 19th week, outer and inner neuroblastic
zones separated by the neuropil were seen. Well defined nerve
fibre layer and inner limiting membrane was present at 18th week.
The outer limiting membrane was first appreciated at 32nd week
of gestation. Foetal retinal pigment epithelium was cuboidal and
filled with melanin granules while no trace of lipofuscin pigment
was found under fluorescent microscope.
Conclusion: Detailed data on retinal histogenesis and its
timeline might aid in directed differentiation of retinal cell types
from stem cells for therapeutic purposes. |
| first_indexed | 2024-12-11T08:59:49Z |
| format | Article |
| id | doaj.art-68bb69913ac44b65a3d65ff832e781dc |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T08:59:49Z |
| publishDate | 2016-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-68bb69913ac44b65a3d65ff832e781dc2022-12-22T01:13:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-03-01103AC04AC0710.7860/JCDR/2016/14936.7372Mapping the Time Line of Development in Each Layer of Human Foetal RetinaTulika Gupta0Kanchan Kapoor1Daisy Sahni2Balbir Singh3Assistant Professor, Department of Anatomy, Post Graduate Institute of Medical Education & Research, Chandigarh, India.Professor, Department of Anatomy, Government Medical College and Hospital, Chandigarh, India.Professor, Department of Anatomy, Post Graduate Institute of Medical Education & Research, Chandigarh, India.Professor, Department of Anatomy, Government Medical College and Hospital, Chandigarh, India.Introduction: There is need to elucidate the histological developmental stages of various layers of retina, to understand the process better and provide clinically significant insights. Aim: To study the details and chronology of in utero development of different layers of retina. Materials and Methods: To study time of appearance, differentiation and organization of all layers of central retina in different gestational age groups. Retina was studied histologically in 27 foetuses from18th to 34th weeks of gestation. Results: We found the period of mid gestation (19th -21st week of gestation) to be the defining time for retinal layers: The bruch’s membrane was fully formed at 20th week of gestation; the photoreceptor layer became well defined at 21st week of gestation; both the nuclear layers and both the plexiform layers and the ganglion cell layer became distinct at 19th week of gestation. Before the 19th week, outer and inner neuroblastic zones separated by the neuropil were seen. Well defined nerve fibre layer and inner limiting membrane was present at 18th week. The outer limiting membrane was first appreciated at 32nd week of gestation. Foetal retinal pigment epithelium was cuboidal and filled with melanin granules while no trace of lipofuscin pigment was found under fluorescent microscope. Conclusion: Detailed data on retinal histogenesis and its timeline might aid in directed differentiation of retinal cell types from stem cells for therapeutic purposes.https://jcdr.net/articles/PDF/7372/14936_CE(RA1)_F(T)_PF1(Vsu_Om)_PFA(NC_AK)_PF2(PAG).pdfbruch’s membranefoetal retinal developmentretinal histogenesisretinal layersretinal pigment epithelium |
| spellingShingle | Tulika Gupta Kanchan Kapoor Daisy Sahni Balbir Singh Mapping the Time Line of Development in Each Layer of Human Foetal Retina Journal of Clinical and Diagnostic Research bruch’s membrane foetal retinal development retinal histogenesis retinal layers retinal pigment epithelium |
| title | Mapping the Time Line of Development in Each Layer of Human Foetal Retina |
| title_full | Mapping the Time Line of Development in Each Layer of Human Foetal Retina |
| title_fullStr | Mapping the Time Line of Development in Each Layer of Human Foetal Retina |
| title_full_unstemmed | Mapping the Time Line of Development in Each Layer of Human Foetal Retina |
| title_short | Mapping the Time Line of Development in Each Layer of Human Foetal Retina |
| title_sort | mapping the time line of development in each layer of human foetal retina |
| topic | bruch’s membrane foetal retinal development retinal histogenesis retinal layers retinal pigment epithelium |
| url | https://jcdr.net/articles/PDF/7372/14936_CE(RA1)_F(T)_PF1(Vsu_Om)_PFA(NC_AK)_PF2(PAG).pdf |
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