Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects
Perchlorate (ClO 4 – ), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 2005–2008 National Health and Nutrition Examina...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-01-01
|
| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S20089 |
| _version_ | 1818863109444468736 |
|---|---|
| author | Dina M. Schreinemachers Andrew J. Ghio Jon R. Sobus Marc A. Williams |
| author_facet | Dina M. Schreinemachers Andrew J. Ghio Jon R. Sobus Marc A. Williams |
| author_sort | Dina M. Schreinemachers |
| collection | DOAJ |
| description | Perchlorate (ClO 4 – ), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 2005–2008 National Health and Nutrition Examination Surveys, investigated associations between urinary perchlorate and biomarkers of iron homeostasis, lipids, blood cell counts, and glucose metabolism. Healthy males (n = 3705), non-pregnant females (n = 2967), and pregnant females (n = 356), aged 12–59 years, were included in the linear regression models, which showed significant positive (+) and negative (−) associations for both males and non-pregnant females with serum uric acid (−), serum iron (−), RBC count (−), blood urea nitrogen (+), and lymphocyte count (+). Other significant associations were observed for either males or non-pregnant females. Among pregnant females, perchlorate was significantly associated with blood urea nitrogen (+) and serum iron (−). These associations may be indicators of perchlorate's potential effect on several biological systems, which when considered in total, may implicate perturbation of iron homeostasis. |
| first_indexed | 2024-12-19T10:10:32Z |
| format | Article |
| id | doaj.art-68bc2db72dfa4925a5befcee8d7b17ac |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-19T10:10:32Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-68bc2db72dfa4925a5befcee8d7b17ac2022-12-21T20:26:24ZengSAGE PublishingBiomarker Insights1177-27192015-01-011010.4137/BMI.S20089Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 SubjectsDina M. Schreinemachers0Andrew J. Ghio1Jon R. Sobus2Marc A. Williams3Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, ORD, US EPA, Durham, NC, USA.Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, ORD, US EPA, Durham, NC, USA.Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, ORD, US EPA, Durham, NC, USA.Current affiliation: U.S. Army MEDCOM Public Health Command, Institute of Public Health, Aberdeen Proving Ground, MD, USA.Perchlorate (ClO 4 – ), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 2005–2008 National Health and Nutrition Examination Surveys, investigated associations between urinary perchlorate and biomarkers of iron homeostasis, lipids, blood cell counts, and glucose metabolism. Healthy males (n = 3705), non-pregnant females (n = 2967), and pregnant females (n = 356), aged 12–59 years, were included in the linear regression models, which showed significant positive (+) and negative (−) associations for both males and non-pregnant females with serum uric acid (−), serum iron (−), RBC count (−), blood urea nitrogen (+), and lymphocyte count (+). Other significant associations were observed for either males or non-pregnant females. Among pregnant females, perchlorate was significantly associated with blood urea nitrogen (+) and serum iron (−). These associations may be indicators of perchlorate's potential effect on several biological systems, which when considered in total, may implicate perturbation of iron homeostasis.https://doi.org/10.4137/BMI.S20089 |
| spellingShingle | Dina M. Schreinemachers Andrew J. Ghio Jon R. Sobus Marc A. Williams Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects Biomarker Insights |
| title | Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects |
| title_full | Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects |
| title_fullStr | Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects |
| title_full_unstemmed | Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects |
| title_short | Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis among NHANES 2005–2008 Subjects |
| title_sort | perchlorate exposure is associated with oxidative stress and indicators of serum iron homeostasis among nhanes 2005 2008 subjects |
| url | https://doi.org/10.4137/BMI.S20089 |
| work_keys_str_mv | AT dinamschreinemachers perchlorateexposureisassociatedwithoxidativestressandindicatorsofserumironhomeostasisamongnhanes20052008subjects AT andrewjghio perchlorateexposureisassociatedwithoxidativestressandindicatorsofserumironhomeostasisamongnhanes20052008subjects AT jonrsobus perchlorateexposureisassociatedwithoxidativestressandindicatorsofserumironhomeostasisamongnhanes20052008subjects AT marcawilliams perchlorateexposureisassociatedwithoxidativestressandindicatorsofserumironhomeostasisamongnhanes20052008subjects |