Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb
<p>Abstract</p> <p>Background</p> <p>Continuous theta burst stimulation (cTBS) is a form of repetitive transcranial magnetic stimulation which has been shown to alter cortical excitability in the upper limb representation of primary somatosensory cortex (SI). However, i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | BMC Neuroscience |
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| Online Access: | http://www.biomedcentral.com/1471-2202/13/133 |
| _version_ | 1818394002686214144 |
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| author | Zapallow Christopher M Asmussen Michael J Bolton David A E Lee Kevin G H Jacobs Mark F Nelson Aimee J |
| author_facet | Zapallow Christopher M Asmussen Michael J Bolton David A E Lee Kevin G H Jacobs Mark F Nelson Aimee J |
| author_sort | Zapallow Christopher M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Continuous theta burst stimulation (cTBS) is a form of repetitive transcranial magnetic stimulation which has been shown to alter cortical excitability in the upper limb representation of primary somatosensory cortex (SI). However, it is unknown whether cTBS modulates cortical excitability within the lower limb representation in SI. The present study investigates the effects of cTBS over the SI lower limb representation on cortical somatosensory evoked potentials (SEPs) and Hoffmann reflex (H-reflex) following tibial nerve stimulation at the knee. SEPs and H-reflex were recorded before and in four time blocks up to 30 minutes following cTBS targeting the lower limb representation within SI.</p> <p>Results</p> <p>Following cTBS, the P1-N1 first cortical potential was significantly decreased at 12–16 minutes. CTBS also suppressed the P2-N2 second cortical potential for up to 30 minutes following stimulation. The H-reflex remained statistically unchanged following cTBS although there was a modest suppression observed.</p> <p>Conclusion</p> <p>We conclude that cTBS decreases cortical excitability of the lower limb representation of SI as evidenced by suppressed SEP amplitude. The duration and magnitude of the cTBS after effects are similar to those observed in upper limb studies.</p> |
| first_indexed | 2024-12-14T05:54:17Z |
| format | Article |
| id | doaj.art-68bcae47c412437ab15b9596a83a2641 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-14T05:54:17Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-68bcae47c412437ab15b9596a83a26412022-12-21T23:14:37ZengBMCBMC Neuroscience1471-22022012-10-0113113310.1186/1471-2202-13-133Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limbZapallow Christopher MAsmussen Michael JBolton David A ELee Kevin G HJacobs Mark FNelson Aimee J<p>Abstract</p> <p>Background</p> <p>Continuous theta burst stimulation (cTBS) is a form of repetitive transcranial magnetic stimulation which has been shown to alter cortical excitability in the upper limb representation of primary somatosensory cortex (SI). However, it is unknown whether cTBS modulates cortical excitability within the lower limb representation in SI. The present study investigates the effects of cTBS over the SI lower limb representation on cortical somatosensory evoked potentials (SEPs) and Hoffmann reflex (H-reflex) following tibial nerve stimulation at the knee. SEPs and H-reflex were recorded before and in four time blocks up to 30 minutes following cTBS targeting the lower limb representation within SI.</p> <p>Results</p> <p>Following cTBS, the P1-N1 first cortical potential was significantly decreased at 12–16 minutes. CTBS also suppressed the P2-N2 second cortical potential for up to 30 minutes following stimulation. The H-reflex remained statistically unchanged following cTBS although there was a modest suppression observed.</p> <p>Conclusion</p> <p>We conclude that cTBS decreases cortical excitability of the lower limb representation of SI as evidenced by suppressed SEP amplitude. The duration and magnitude of the cTBS after effects are similar to those observed in upper limb studies.</p>http://www.biomedcentral.com/1471-2202/13/133Continuous theta burst stimulationSomatosensory evoked potentialsHoffmann reflexLower limb |
| spellingShingle | Zapallow Christopher M Asmussen Michael J Bolton David A E Lee Kevin G H Jacobs Mark F Nelson Aimee J Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb BMC Neuroscience Continuous theta burst stimulation Somatosensory evoked potentials Hoffmann reflex Lower limb |
| title | Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| title_full | Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| title_fullStr | Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| title_full_unstemmed | Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| title_short | Theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| title_sort | theta burst repetitive transcranial magnetic stimulation attenuates somatosensory evoked potentials from the lower limb |
| topic | Continuous theta burst stimulation Somatosensory evoked potentials Hoffmann reflex Lower limb |
| url | http://www.biomedcentral.com/1471-2202/13/133 |
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