A review of the effects of Urtica dioica (nettle) in metabolic syndrome
Metabolic syndrome is a serious health condition, yet a common worldwide disorder. It includes several risk factors such as hypertension, dyslipidemia, and high glucose levels which lead the patients to higher risks of cardiovascular diseases, diabetes, and stroke. Phytotherapy plays an important ro...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-05-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_20173_1909073c9af11a9bb81515e039e763b6.pdf |
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| author | Bahareh Samakar Soghra Mehri Hossein Hosseinzadeh |
| author_facet | Bahareh Samakar Soghra Mehri Hossein Hosseinzadeh |
| author_sort | Bahareh Samakar |
| collection | DOAJ |
| description | Metabolic syndrome is a serious health condition, yet a common worldwide disorder. It includes several risk factors such as hypertension, dyslipidemia, and high glucose levels which lead the patients to higher risks of cardiovascular diseases, diabetes, and stroke. Phytotherapy plays an important role in treating components of metabolic syndrome. Nettle (Urtica dioica) is considered a valuable plant due to bioactive compounds such as formic acid and rich sources of flavonoids. To acknowledge the role of nettle in metabolic syndrome, several mechanisms have been suggested such as alterations in potassium and calcium channels which improve hypertension. Antihyperlipidemic properties of nettle are mediated by inhibition of HMGCoA reductase and amelioration of lipid peroxidation via antioxidant effects. Also, one of the flavonoids in nettle, quercetin, is responsible for decreasing total cholesterol. Moreover, nettle is responsible for anti-diabetic effects through processes such as increasing insulin secretion and proliferation of pancreatic β-cells. This review aims to gather different studies to confirm the potential efficacy of nettle in metabolic syndrome. |
| first_indexed | 2024-04-11T23:54:05Z |
| format | Article |
| id | doaj.art-68c03873cd3a405190bfe81762cf73d4 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-11T23:54:05Z |
| publishDate | 2022-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-68c03873cd3a405190bfe81762cf73d42022-12-22T03:56:25ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-05-0125554355310.22038/ijbms.2022.58892.1307920173A review of the effects of Urtica dioica (nettle) in metabolic syndromeBahareh Samakar0Soghra Mehri1Hossein Hosseinzadeh2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranMetabolic syndrome is a serious health condition, yet a common worldwide disorder. It includes several risk factors such as hypertension, dyslipidemia, and high glucose levels which lead the patients to higher risks of cardiovascular diseases, diabetes, and stroke. Phytotherapy plays an important role in treating components of metabolic syndrome. Nettle (Urtica dioica) is considered a valuable plant due to bioactive compounds such as formic acid and rich sources of flavonoids. To acknowledge the role of nettle in metabolic syndrome, several mechanisms have been suggested such as alterations in potassium and calcium channels which improve hypertension. Antihyperlipidemic properties of nettle are mediated by inhibition of HMGCoA reductase and amelioration of lipid peroxidation via antioxidant effects. Also, one of the flavonoids in nettle, quercetin, is responsible for decreasing total cholesterol. Moreover, nettle is responsible for anti-diabetic effects through processes such as increasing insulin secretion and proliferation of pancreatic β-cells. This review aims to gather different studies to confirm the potential efficacy of nettle in metabolic syndrome.https://ijbms.mums.ac.ir/article_20173_1909073c9af11a9bb81515e039e763b6.pdfdiabeteshyperlipidemiahypertensionmetabolic syndromenettleurtica dioica |
| spellingShingle | Bahareh Samakar Soghra Mehri Hossein Hosseinzadeh A review of the effects of Urtica dioica (nettle) in metabolic syndrome Iranian Journal of Basic Medical Sciences diabetes hyperlipidemia hypertension metabolic syndrome nettle urtica dioica |
| title | A review of the effects of Urtica dioica (nettle) in metabolic syndrome |
| title_full | A review of the effects of Urtica dioica (nettle) in metabolic syndrome |
| title_fullStr | A review of the effects of Urtica dioica (nettle) in metabolic syndrome |
| title_full_unstemmed | A review of the effects of Urtica dioica (nettle) in metabolic syndrome |
| title_short | A review of the effects of Urtica dioica (nettle) in metabolic syndrome |
| title_sort | review of the effects of urtica dioica nettle in metabolic syndrome |
| topic | diabetes hyperlipidemia hypertension metabolic syndrome nettle urtica dioica |
| url | https://ijbms.mums.ac.ir/article_20173_1909073c9af11a9bb81515e039e763b6.pdf |
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