Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis
BackgroundDementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.955878/full |
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| author | Rangyin Zhao Rangyin Zhao Xiaoyong Han Hongxia Zhang Jia Liu Min Zhang Weijing Zhao Shangrong Jiang Ruilin Li Hui Cai Hui Cai Hui Cai Hui Cai Hong You |
| author_facet | Rangyin Zhao Rangyin Zhao Xiaoyong Han Hongxia Zhang Jia Liu Min Zhang Weijing Zhao Shangrong Jiang Ruilin Li Hui Cai Hui Cai Hui Cai Hui Cai Hong You |
| author_sort | Rangyin Zhao |
| collection | DOAJ |
| description | BackgroundDementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them.MethodsWe searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords “dementia,” “Alzheimer's disease,” “vitamin E,” and “tocopherol,” and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software.ResultsWe included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70–0.88 I2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64–0.94 I2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score.ConclusionsHigh vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease. |
| first_indexed | 2024-04-14T07:36:44Z |
| format | Article |
| id | doaj.art-68c0d1bda6a9495ea217ef6a0c24cf4c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-14T07:36:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-68c0d1bda6a9495ea217ef6a0c24cf4c2022-12-22T02:05:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.955878955878Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysisRangyin Zhao0Rangyin Zhao1Xiaoyong Han2Hongxia Zhang3Jia Liu4Min Zhang5Weijing Zhao6Shangrong Jiang7Ruilin Li8Hui Cai9Hui Cai10Hui Cai11Hui Cai12Hong You13Gansu University of Chinese Medicine, First Clinical Medical College, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaGraduate School, Ning Xia Medical University, Yinchuan, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaLanzhou No.1 People's Hospital, Lanzhou, ChinaGeneral Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, ChinaKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Lanzhou, ChinaFirst Clinical College of Medicine, Lanzhou University, Lanzhou, ChinaNHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, ChinaSino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, ChinaBackgroundDementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them.MethodsWe searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords “dementia,” “Alzheimer's disease,” “vitamin E,” and “tocopherol,” and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software.ResultsWe included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70–0.88 I2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64–0.94 I2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score.ConclusionsHigh vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease.https://www.frontiersin.org/articles/10.3389/fnagi.2022.955878/fullvitamin Edietsupplementsdementiariskmeta-analysis |
| spellingShingle | Rangyin Zhao Rangyin Zhao Xiaoyong Han Hongxia Zhang Jia Liu Min Zhang Weijing Zhao Shangrong Jiang Ruilin Li Hui Cai Hui Cai Hui Cai Hui Cai Hong You Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis Frontiers in Aging Neuroscience vitamin E diet supplements dementia risk meta-analysis |
| title | Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis |
| title_full | Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis |
| title_fullStr | Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis |
| title_full_unstemmed | Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis |
| title_short | Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis |
| title_sort | association of vitamin e intake in diet and supplements with risk of dementia a meta analysis |
| topic | vitamin E diet supplements dementia risk meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.955878/full |
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