Investigation of procoagulant activity in extracellular vesicles isolated by differential ultracentrifugation

Investigation of procoagulant activity in extracellular vesicles isolated by differential ultracentrifugation

Tissue factor (TF) is the main initiator of coagulation and procoagulant phospholipids (PPL) are key components in promoting coagulation activity in blood. Both TF and PPL may be presented on the surface of extracellular vesicles (EVs), thus contributing to their procoagulant activity. These EVs may...

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Bibliographic Details
Main Authors: Thøger Nielsen, Anne Flou Kristensen, Shona Pedersen, Gunna Christiansen, Søren Risom Kristensen
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Electron microscopy
extracellular vesicles
isolation
microvesicles
thrombin generation
tissue factor
procoagulant phospholipids
Online Access:http://dx.doi.org/10.1080/20013078.2018.1454777

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