In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in <i>Leishmania</i> spp.

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in <i>Leishmania</i> spp.

Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect the <i>Leishmania</i> spp. multiplication, there are gaps in...

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Bibliographic Details
Main Authors: Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
<i>Leishmania</i> spp.
leishmaniases
epoxy-α-lapachone
epoxymethyl-lawsone
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/12/3537

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