MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid art...
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Bibliographic Details
| Main Authors: |
Stefano Alivernini,
Mariola Kurowska-Stolarska,
Barbara Tolusso,
Roberta Benvenuto,
Aziza Elmesmari,
Silvia Canestri,
Luca Petricca,
Antonella Mangoni,
Anna Laura Fedele,
Clara Di Mario,
Maria Rita Gigante,
Elisa Gremese,
Iain B. McInnes,
Gianfranco Ferraccioli |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12970
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