Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria
Background: Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation. Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia. Methods...
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| Format: | Article |
| Language: | English |
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Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu
2023-09-01
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| Series: | Annals of Health Research |
| Subjects: | |
| Online Access: | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/512 |
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| author | Nnachi OC Edenya OO Okoye HC Akpa CO Nwani FO Nwani EI |
| author_facet | Nnachi OC Edenya OO Okoye HC Akpa CO Nwani FO Nwani EI |
| author_sort | Nnachi OC |
| collection | DOAJ |
| description | Background: Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation.
Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia.
Methods: A cross-sectional study design was used for the survey. A total of 50 patients with sickle cell anaemia and 50 controls without SCD were recruited for the study. The clinical data and plasma lipid levels of lipids and haemoglobin parameters were analysed.
Results: The majority of the participants were aged 18-25 years. Total plasma cholesterol and HDL-C were significantly lower in individuals with SCA compared with the controls (3.3±1.2 vs 4.2±1.2; p<0.001) and (1.3±0.5 vs 1.5±0.4; p = 0.038) respectively. Most patients with SCA had moderate disease severity (24; 48%). There was no statistically significant difference in the plasma levels of total cholesterol and HDL-C across the disease severity groups of SCA (p = 0.694 and 0.262). There was also no significant correlation between total cholesterol, HDL-C, and markers of haemolysis, haemoglobin F, and haemoglobin S levels.
Conclusion: SCA is characterised by lower mean plasma TC and HDL than controls. However, no relationship was found between TC, HDL levels and SCD disease severity, markers of haemolysis, HbF and HbS levels. Further studies are required to ascertain the implications of plasma lipid levels in SCD. |
| first_indexed | 2024-03-07T21:59:05Z |
| format | Article |
| id | doaj.art-68c316d8e0f74b73ac2c0caaf857d5f1 |
| institution | Directory Open Access Journal |
| issn | 2476-8642 2536-6149 |
| language | English |
| last_indexed | 2024-03-07T21:59:05Z |
| publishDate | 2023-09-01 |
| publisher | Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu |
| record_format | Article |
| series | Annals of Health Research |
| spelling | doaj.art-68c316d8e0f74b73ac2c0caaf857d5f12024-02-24T06:42:58ZengMedical and Dental Consultants Association of Nigeria, OOUTH SagamuAnnals of Health Research2476-86422536-61492023-09-019324725710.30442/ahr.0903-08-210Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast NigeriaNnachi OChttps://orcid.org/0000-0002-9393-3920Edenya OOOkoye HCAkpa CONwani FONwani EIBackground: Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation. Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia. Methods: A cross-sectional study design was used for the survey. A total of 50 patients with sickle cell anaemia and 50 controls without SCD were recruited for the study. The clinical data and plasma lipid levels of lipids and haemoglobin parameters were analysed. Results: The majority of the participants were aged 18-25 years. Total plasma cholesterol and HDL-C were significantly lower in individuals with SCA compared with the controls (3.3±1.2 vs 4.2±1.2; p<0.001) and (1.3±0.5 vs 1.5±0.4; p = 0.038) respectively. Most patients with SCA had moderate disease severity (24; 48%). There was no statistically significant difference in the plasma levels of total cholesterol and HDL-C across the disease severity groups of SCA (p = 0.694 and 0.262). There was also no significant correlation between total cholesterol, HDL-C, and markers of haemolysis, haemoglobin F, and haemoglobin S levels. Conclusion: SCA is characterised by lower mean plasma TC and HDL than controls. However, no relationship was found between TC, HDL levels and SCD disease severity, markers of haemolysis, HbF and HbS levels. Further studies are required to ascertain the implications of plasma lipid levels in SCD.https://www.annalsofhealthresearch.com/index.php/ahr/article/view/512cholesterolhaemoglobinopathyhigh-density lipoprotein-cholesterolsickle cell diseasetotal cholesterol |
| spellingShingle | Nnachi OC Edenya OO Okoye HC Akpa CO Nwani FO Nwani EI Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria Annals of Health Research cholesterol haemoglobinopathy high-density lipoprotein-cholesterol sickle cell disease total cholesterol |
| title | Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria |
| title_full | Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria |
| title_fullStr | Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria |
| title_full_unstemmed | Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria |
| title_short | Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria |
| title_sort | plasma lipid levels in relation to disease severity in sickle cell anaemia in abakaliki southeast nigeria |
| topic | cholesterol haemoglobinopathy high-density lipoprotein-cholesterol sickle cell disease total cholesterol |
| url | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/512 |
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