Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders

Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders

Neurodegenerative disorders have been shown to exhibit substantial interconnectedness with circadian rhythmicity. Alzheimer’s patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and Parkinson’s patients have highly disrupted peripheral...

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Bibliographic Details
Main Authors: Arastu Sharma, Sehyun Lee, Hoonseo Kim, Hargsoon Yoon, Shinwon Ha, Sung Ung Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
circadian rhythm
DNA damage
PARP1
PAR-dependent E3 ligase
α-synuclein pre-formed fibrils
β-amyloid peptides
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00844/full

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