| Summary: | This study examined the effects of curcumin and fenugreek soluble fiber supplementation on the ventilatory threshold (VT) and peak oxygen consumption (<inline-formula> <math display="inline"> <semantics> <mrow> <mover accent="true"> <mi mathvariant="normal">V</mi> <mo>˙</mo> </mover> </mrow> </semantics> </math> </inline-formula>O<sub>2</sub> peak). Methods: Forty-five untrained men and women were randomly assigned to one of three supplementation groups: placebo (PLA, <i>n</i> = 13), 500 mg·day<sup>−1</sup> CurQfen<sup>®</sup> (CUR, <i>n</i> = 14), or 300 mg·day<sup>−1</sup> fenugreek soluble fiber (FEN, <i>n</i> = 18). Participants completed a maximal graded exercise test on a cycle ergometer to determine the VT and <inline-formula> <math display="inline"> <semantics> <mrow> <mover accent="true"> <mi mathvariant="normal">V</mi> <mo>˙</mo> </mover> </mrow> </semantics> </math> </inline-formula>O<sub>2</sub> peak before (PRE) and after (POST) 28 days of daily supplementation. Separate, one-way analyses of covariance (ANCOVAs) were used to examine the between-group differences for adjusted POST VT and <inline-formula> <math display="inline"> <semantics> <mrow> <mover accent="true"> <mi mathvariant="normal">V</mi> <mo>˙</mo> </mover> </mrow> </semantics> </math> </inline-formula>O<sub>2</sub> peak values, covaried for the respective PRE-test values. Results: The adjusted POST VT <inline-formula> <math display="inline"> <semantics> <mrow> <mover accent="true"> <mi mathvariant="normal">V</mi> <mo>˙</mo> </mover> </mrow> </semantics> </math> </inline-formula>O<sub>2</sub> values for the CUR (mean ± SD = 1.593 ± 0.157 L·min<sup>−1</sup>) and FEN (1.597 ± 0.157 L·min<sup>−1</sup>) groups were greater than (<i>p</i> = 0.039 and <i>p</i> = 0.025, respectively) the PLA (1.465 ± 0.155 L·min<sup>−1</sup>) group, but the FEN and CUR groups were not different (<i>p</i> = 0.943). There were no differences in the adjusted <inline-formula> <math display="inline"> <semantics> <mrow> <mover accent="true"> <mi mathvariant="normal">V</mi> <mo>˙</mo> </mover> </mrow> </semantics> </math> </inline-formula>O<sub>2</sub> peak values (F = 0.613, <i>p</i> = 0.547) among groups. Conclusion: These findings indicated that fenugreek soluble fiber was responsible for the improvements in the submaximal performance index for both CUR and FEN groups.
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