The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway
The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-lik...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-08-01
|
| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2022-0302 |
| _version_ | 1797736142031814656 |
|---|---|
| author | Kuang Guiying Shu Zhigang Zhu Chunli Li Hongbing Zhang Cheng |
| author_facet | Kuang Guiying Shu Zhigang Zhu Chunli Li Hongbing Zhang Cheng |
| author_sort | Kuang Guiying |
| collection | DOAJ |
| description | The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-like domains (Ang receptor) 2 (Tie-2) signaling pathways, which may underlie the cognitive improvement observed in CCH rats. |
| first_indexed | 2024-03-12T13:09:18Z |
| format | Article |
| id | doaj.art-68c642c1351d46898ce1de4e262e5b86 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-03-12T13:09:18Z |
| publishDate | 2023-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-68c642c1351d46898ce1de4e262e5b862023-08-28T06:16:40ZengDe GruyterTranslational Neuroscience2081-69362023-08-0114141210.1515/tnsci-2022-0302The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathwayKuang Guiying0Shu Zhigang1Zhu Chunli2Li Hongbing3Zhang Cheng4Neurological Department, Wuhan Red Cross Hospital, Wuhan, Hubei Province, 436015, ChinaNeurological Department, Ezhou Central Hospital, Ezhou, Hubei Province, 436000, ChinaNeurological Department, Wuhan Red Cross Hospital, Wuhan, Hubei Province, 436015, ChinaEmergency Department, The First People’s Hospital of Guiyang, Guiyang, Guizhou Province, 550002, ChinaEmergency Department, The First People’s Hospital of Guiyang, Guiyang, Guizhou Province, 550002, ChinaThe objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-like domains (Ang receptor) 2 (Tie-2) signaling pathways, which may underlie the cognitive improvement observed in CCH rats.https://doi.org/10.1515/tnsci-2022-0302modified dioscorea pillschronic cerebral hypoperfusionang/tie signaling pathwaymicrovessel density |
| spellingShingle | Kuang Guiying Shu Zhigang Zhu Chunli Li Hongbing Zhang Cheng The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway Translational Neuroscience modified dioscorea pills chronic cerebral hypoperfusion ang/tie signaling pathway microvessel density |
| title | The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway |
| title_full | The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway |
| title_fullStr | The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway |
| title_full_unstemmed | The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway |
| title_short | The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway |
| title_sort | promoting effect of modified dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the ang tie signaling pathway |
| topic | modified dioscorea pills chronic cerebral hypoperfusion ang/tie signaling pathway microvessel density |
| url | https://doi.org/10.1515/tnsci-2022-0302 |
| work_keys_str_mv | AT kuangguiying thepromotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT shuzhigang thepromotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT zhuchunli thepromotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT lihongbing thepromotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT zhangcheng thepromotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT kuangguiying promotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT shuzhigang promotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT zhuchunli promotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT lihongbing promotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway AT zhangcheng promotingeffectofmodifieddioscoreapillsonvascularremodelinginchroniccerebralhypoperfusionviatheangtiesignalingpathway |