Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives
ABSTRACTThe gut microbiota is a complex and diverse ecosystem comprised of trillions of microbes and plays an essential role in host’s immunity, metabolism, and even behaviors. Environmental and host factors drive the huge variations in the gut microbiome among individuals. Here, we summarize accumu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2205410 |
| _version_ | 1797236653072318464 |
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| author | Lusheng Huang Congying Chen |
| author_facet | Lusheng Huang Congying Chen |
| author_sort | Lusheng Huang |
| collection | DOAJ |
| description | ABSTRACTThe gut microbiota is a complex and diverse ecosystem comprised of trillions of microbes and plays an essential role in host’s immunity, metabolism, and even behaviors. Environmental and host factors drive the huge variations in the gut microbiome among individuals. Here, we summarize accumulated evidences about host genetic effect on the gut microbial compositions with emphases on the correlation between host genetic kinship and the similarity of microbial compositions, heritability estimates of microbial taxa, and identification of genomic variants associated with the gut microbiome in pigs as well as in humans. A proportion of bacterial taxa have been reported to be heritable, and numerous variants associated with the diversity of the gut microbiota or specific taxa have been identified in both humans and pigs. LCT and ABO gene have been replicated in multiple studies, and its mechanism have been elucidated clearly. We also discuss the main advantages and challenges using pigs as experimental animals in exploring host genetic effect on the gut microbial composition and provided our insights on the perspectives in this area. |
| first_indexed | 2024-03-11T14:19:16Z |
| format | Article |
| id | doaj.art-68c680a8ba894f17aed95ed4ae8dc64e |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:16Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-68c680a8ba894f17aed95ed4ae8dc64e2024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2205410Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectivesLusheng Huang0Congying Chen1National Key Laboratory of Pig Genetic Improvement, Jiangxi Agricultural University, Nanchang, ChinaNational Key Laboratory of Pig Genetic Improvement, Jiangxi Agricultural University, Nanchang, ChinaABSTRACTThe gut microbiota is a complex and diverse ecosystem comprised of trillions of microbes and plays an essential role in host’s immunity, metabolism, and even behaviors. Environmental and host factors drive the huge variations in the gut microbiome among individuals. Here, we summarize accumulated evidences about host genetic effect on the gut microbial compositions with emphases on the correlation between host genetic kinship and the similarity of microbial compositions, heritability estimates of microbial taxa, and identification of genomic variants associated with the gut microbiome in pigs as well as in humans. A proportion of bacterial taxa have been reported to be heritable, and numerous variants associated with the diversity of the gut microbiota or specific taxa have been identified in both humans and pigs. LCT and ABO gene have been replicated in multiple studies, and its mechanism have been elucidated clearly. We also discuss the main advantages and challenges using pigs as experimental animals in exploring host genetic effect on the gut microbial composition and provided our insights on the perspectives in this area.https://www.tandfonline.com/doi/10.1080/19490976.2023.2205410Gut microbiomehost geneticsheritability estimatesgenome-wide association studypigs |
| spellingShingle | Lusheng Huang Congying Chen Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives Gut Microbes Gut microbiome host genetics heritability estimates genome-wide association study pigs |
| title | Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives |
| title_full | Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives |
| title_fullStr | Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives |
| title_full_unstemmed | Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives |
| title_short | Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives |
| title_sort | employing pigs to decipher the host genetic effect on gut microbiome advantages challenges and perspectives |
| topic | Gut microbiome host genetics heritability estimates genome-wide association study pigs |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2205410 |
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