New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review
Since 31 December 2019, the coronavirus disease 2019 (COVID-19) resulted in a state of hyperinflammation syndrome and multiorgan failure. In areas with pandemic outbreaks, despite several emerging vaccines, supportive treatments to mitigate fatality rates were required. Growing evidence suggests th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2022-03-01
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| Series: | Men's Health Journal |
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| Online Access: | https://journals.sbmu.ac.ir/mhj/article/view/35556 |
| _version_ | 1818285998561296384 |
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| author | Mohammad Ali Salahshoor Reza Mahjub |
| author_facet | Mohammad Ali Salahshoor Reza Mahjub |
| author_sort | Mohammad Ali Salahshoor |
| collection | DOAJ |
| description |
Since 31 December 2019, the coronavirus disease 2019 (COVID-19) resulted in a state of hyperinflammation syndrome and multiorgan failure. In areas with pandemic outbreaks, despite several emerging vaccines, supportive treatments to mitigate fatality rates were required. Growing evidence suggests that several small RNAs such as microRNAs (miRNAs) and short interfering RNA (siRNA) could be candidates for the treatment of COVID-19 by inhibiting the expression of crucial virus genes. small RNAs by binding to the 3′-untranslated region (UTR) or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. In this review, the authors sought to specify the efficacy and safety of miRNAs and siRNA expressions of patients with COVID-19, which has an axial role in the pathogenesis of human diseases.
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| first_indexed | 2024-12-13T01:17:36Z |
| format | Article |
| id | doaj.art-68c83db034ad4bdd803e1bebe784f79c |
| institution | Directory Open Access Journal |
| issn | 2645-3614 |
| language | English |
| last_indexed | 2024-12-13T01:17:36Z |
| publishDate | 2022-03-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Men's Health Journal |
| spelling | doaj.art-68c83db034ad4bdd803e1bebe784f79c2022-12-22T00:04:18ZengShahid Beheshti University of Medical SciencesMen's Health Journal2645-36142022-03-016110.22037/mhj.v6i1.35556New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative ReviewMohammad Ali Salahshoor0Reza MahjubFaculty of Pharmacy, Department of Pharmaceutics, Hamadan University of Medical Sciences, Hamadan, Iran Since 31 December 2019, the coronavirus disease 2019 (COVID-19) resulted in a state of hyperinflammation syndrome and multiorgan failure. In areas with pandemic outbreaks, despite several emerging vaccines, supportive treatments to mitigate fatality rates were required. Growing evidence suggests that several small RNAs such as microRNAs (miRNAs) and short interfering RNA (siRNA) could be candidates for the treatment of COVID-19 by inhibiting the expression of crucial virus genes. small RNAs by binding to the 3′-untranslated region (UTR) or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. In this review, the authors sought to specify the efficacy and safety of miRNAs and siRNA expressions of patients with COVID-19, which has an axial role in the pathogenesis of human diseases. https://journals.sbmu.ac.ir/mhj/article/view/35556COVID-19miRNAssiRNATreatment |
| spellingShingle | Mohammad Ali Salahshoor Reza Mahjub New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review Men's Health Journal COVID-19 miRNAs siRNA Treatment |
| title | New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review |
| title_full | New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review |
| title_fullStr | New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review |
| title_full_unstemmed | New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review |
| title_short | New Insight about of microRNAs & short interfering RNA in Treatment of COVID-19; a Narrative Review |
| title_sort | new insight about of micrornas short interfering rna in treatment of covid 19 a narrative review |
| topic | COVID-19 miRNAs siRNA Treatment |
| url | https://journals.sbmu.ac.ir/mhj/article/view/35556 |
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