Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults
Background Left ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.009041 |
| _version_ | 1818315353863749632 |
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| author | Elizabeth E. Moore Dandan Liu Kimberly R. Pechman James G. Terry Sangeeta Nair Francis E. Cambronero Susan P. Bell Katherine A. Gifford Adam W. Anderson Timothy J. Hohman John Jeffrey Carr Angela L. Jefferson |
| author_facet | Elizabeth E. Moore Dandan Liu Kimberly R. Pechman James G. Terry Sangeeta Nair Francis E. Cambronero Susan P. Bell Katherine A. Gifford Adam W. Anderson Timothy J. Hohman John Jeffrey Carr Angela L. Jefferson |
| author_sort | Elizabeth E. Moore |
| collection | DOAJ |
| description | Background Left ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults with normal cognition and mild cognitive impairment. Methods and Results Vanderbilt Memory & Aging Project participants free of clinical stroke, dementia, and heart failure (n=318, 73±7 years, 58% male, 39% mild cognitive impairment) underwent brain magnetic resonance imaging, cardiac magnetic resonance, and neuropsychological assessment. Voxelwise analyses related LV mass index (g/m2) to diffusion tensor imaging metrics. Models adjusted for age, sex, education, race/ethnicity, Framingham Stroke Risk Profile, cognitive diagnosis, and apolipoprotein E–ε4 status. Secondary analyses included a LV mass index×diagnosis interaction term with follow‐up models stratified by diagnosis. With identical covariates, linear regression models related LV mass index to neuropsychological performances. Increased LV mass index related to altered white matter microstructure (P<0.05). In models stratified by diagnosis, associations between LV mass index and diffusion tensor imaging were present among mild cognitive impairment participants only (P<0.05). LV mass index was related only to worse visuospatial memory performance (β=−0.003, P=0.036), an observation that would not withstand correction for multiple testing. Conclusions In the absence of prevalent heart failure and clinical stroke, increased LV mass index corresponds to altered white matter microstructure, particularly among older adults with clinical symptoms of prodromal dementia. Findings highlight the potential link between subclinical LV remodeling and cerebral white matter microstructure vulnerability. |
| first_indexed | 2024-12-13T09:04:12Z |
| format | Article |
| id | doaj.art-68cae9dda4f0476e97266a9f7549a1fc |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T09:04:12Z |
| publishDate | 2018-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-68cae9dda4f0476e97266a9f7549a1fc2022-12-21T23:53:06ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-07-0171310.1161/JAHA.118.009041Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older AdultsElizabeth E. Moore0Dandan Liu1Kimberly R. Pechman2James G. Terry3Sangeeta Nair4Francis E. Cambronero5Susan P. Bell6Katherine A. Gifford7Adam W. Anderson8Timothy J. Hohman9John Jeffrey Carr10Angela L. Jefferson11Department of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Biostatistics Vanderbilt University Medical Center Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Radiology & Radiological Sciences Vanderbilt University Medical Center Nashville TNDepartment of Radiology & Radiological Sciences Vanderbilt University Medical Center Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Biomedical Engineering Vanderbilt University Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNDepartment of Radiology & Radiological Sciences Vanderbilt University Medical Center Nashville TNDepartment of Neurology Vanderbilt Memory & Alzheimer's Center Vanderbilt University Medical Center Nashville TNBackground Left ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults with normal cognition and mild cognitive impairment. Methods and Results Vanderbilt Memory & Aging Project participants free of clinical stroke, dementia, and heart failure (n=318, 73±7 years, 58% male, 39% mild cognitive impairment) underwent brain magnetic resonance imaging, cardiac magnetic resonance, and neuropsychological assessment. Voxelwise analyses related LV mass index (g/m2) to diffusion tensor imaging metrics. Models adjusted for age, sex, education, race/ethnicity, Framingham Stroke Risk Profile, cognitive diagnosis, and apolipoprotein E–ε4 status. Secondary analyses included a LV mass index×diagnosis interaction term with follow‐up models stratified by diagnosis. With identical covariates, linear regression models related LV mass index to neuropsychological performances. Increased LV mass index related to altered white matter microstructure (P<0.05). In models stratified by diagnosis, associations between LV mass index and diffusion tensor imaging were present among mild cognitive impairment participants only (P<0.05). LV mass index was related only to worse visuospatial memory performance (β=−0.003, P=0.036), an observation that would not withstand correction for multiple testing. Conclusions In the absence of prevalent heart failure and clinical stroke, increased LV mass index corresponds to altered white matter microstructure, particularly among older adults with clinical symptoms of prodromal dementia. Findings highlight the potential link between subclinical LV remodeling and cerebral white matter microstructure vulnerability.https://www.ahajournals.org/doi/10.1161/JAHA.118.009041cognitive impairmentdiffusion‐weighted imagingleft ventricular masswhite matter disease |
| spellingShingle | Elizabeth E. Moore Dandan Liu Kimberly R. Pechman James G. Terry Sangeeta Nair Francis E. Cambronero Susan P. Bell Katherine A. Gifford Adam W. Anderson Timothy J. Hohman John Jeffrey Carr Angela L. Jefferson Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cognitive impairment diffusion‐weighted imaging left ventricular mass white matter disease |
| title | Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults |
| title_full | Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults |
| title_fullStr | Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults |
| title_full_unstemmed | Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults |
| title_short | Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults |
| title_sort | increased left ventricular mass index is associated with compromised white matter microstructure among older adults |
| topic | cognitive impairment diffusion‐weighted imaging left ventricular mass white matter disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.009041 |
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