Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle
Background and purpose: One of the problems of in vitro fertilization (IVF) cycles is recurrent failure of implantation. The present study aimed to investigate the effect of intrauterine saline infusion in luteal phase of previous menstrual cycle on occurrence of pregnancy in infertile patients unde...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-16758-en.html |
| _version_ | 1797943919642673152 |
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| author | Marzieh Zamaniyan Noushin Gordani Sepideh Peivandi Mahsa Golshani Mohammad Khademloo Fatemeh Kalantari Fatemeh Yahyapour Aghmashhadi |
| author_facet | Marzieh Zamaniyan Noushin Gordani Sepideh Peivandi Mahsa Golshani Mohammad Khademloo Fatemeh Kalantari Fatemeh Yahyapour Aghmashhadi |
| author_sort | Marzieh Zamaniyan |
| collection | DOAJ |
| description | Background and purpose: One of the problems of in vitro fertilization (IVF) cycles is recurrent failure of implantation. The present study aimed to investigate the effect of intrauterine saline infusion in luteal phase of previous menstrual cycle on occurrence of pregnancy in infertile patients undergoing frozen-thawed embryo transfer.
Materials and methods: This clinical trial was conducted in 70 infertile women attending the infertility center in Sari Imam Khomeini Hospital who were undergoing frozen-thawed embryo transfer in 2020. The participants were randomly divided into an intervention group and a control group (n= 35 per group) using random number table. In intervention group, intrauterine injection of saline with ultrasound guidance was performed on day 21 of previous menstrual cycle, while the control group received no intervention. Pregnancy outcomes were compared between the two groups. Data analysis was performed using Chi-square and t-test.
Results: The intervention group and control group were found to be significantly different in rate of clinical pregnancy (6.5%, 28.1%) (P=0.003) and live birth (6.5%, 28.1%), respectively (P=0.02).
Conclusion: In this study, saline infusion sonohysterography did not have positive effect on clinical pregnancy and live birth, which could be due to small sample size, performing the procedure on day 21 of cycle, or ineffectiveness of this method in causing inflammation following scratches compared to conventional methods. Further molecular and cellular studies are needed to compare the effect of these methods on increasing the level of inflammatory factors.
(Clinical Trials Registry Number: IRCT20160815029374N8) |
| first_indexed | 2024-04-10T20:31:43Z |
| format | Article |
| id | doaj.art-68cb6b7a0cdc4d28bb796b53b10b8e1f |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:31:43Z |
| publishDate | 2021-10-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-68cb6b7a0cdc4d28bb796b53b10b8e1f2023-01-25T06:07:29ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-10-01312015969Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer CycleMarzieh Zamaniyan0Noushin Gordani1Sepideh Peivandi2Mahsa Golshani3Mohammad Khademloo4Fatemeh Kalantari5Fatemeh Yahyapour Aghmashhadi6 Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran 2 Associate Professor, Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran MSc in Counseling in Midwifery, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran Resident in Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Associate Associate Professor, Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran BSc in Nursing, Mazandaran University of Medical Sciences, Sari, Iran BSc in Midwifery, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: One of the problems of in vitro fertilization (IVF) cycles is recurrent failure of implantation. The present study aimed to investigate the effect of intrauterine saline infusion in luteal phase of previous menstrual cycle on occurrence of pregnancy in infertile patients undergoing frozen-thawed embryo transfer. Materials and methods: This clinical trial was conducted in 70 infertile women attending the infertility center in Sari Imam Khomeini Hospital who were undergoing frozen-thawed embryo transfer in 2020. The participants were randomly divided into an intervention group and a control group (n= 35 per group) using random number table. In intervention group, intrauterine injection of saline with ultrasound guidance was performed on day 21 of previous menstrual cycle, while the control group received no intervention. Pregnancy outcomes were compared between the two groups. Data analysis was performed using Chi-square and t-test. Results: The intervention group and control group were found to be significantly different in rate of clinical pregnancy (6.5%, 28.1%) (P=0.003) and live birth (6.5%, 28.1%), respectively (P=0.02). Conclusion: In this study, saline infusion sonohysterography did not have positive effect on clinical pregnancy and live birth, which could be due to small sample size, performing the procedure on day 21 of cycle, or ineffectiveness of this method in causing inflammation following scratches compared to conventional methods. Further molecular and cellular studies are needed to compare the effect of these methods on increasing the level of inflammatory factors. (Clinical Trials Registry Number: IRCT20160815029374N8)http://jmums.mazums.ac.ir/article-1-16758-en.htmlsonohysterographyin vitro fertilizationinfertilitypregnancyendometrial injury |
| spellingShingle | Marzieh Zamaniyan Noushin Gordani Sepideh Peivandi Mahsa Golshani Mohammad Khademloo Fatemeh Kalantari Fatemeh Yahyapour Aghmashhadi Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle Journal of Mazandaran University of Medical Sciences sonohysterography in vitro fertilization infertility pregnancy endometrial injury |
| title | Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle |
| title_full | Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle |
| title_fullStr | Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle |
| title_full_unstemmed | Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle |
| title_short | Effect of Saline Infusion Sonohystrography in Luteal Phase of Previous Menstrual Cycle on Pregnancy Rate in Infertile Women Undergoing Frozen-Thawed Embryo Transfer Cycle |
| title_sort | effect of saline infusion sonohystrography in luteal phase of previous menstrual cycle on pregnancy rate in infertile women undergoing frozen thawed embryo transfer cycle |
| topic | sonohysterography in vitro fertilization infertility pregnancy endometrial injury |
| url | http://jmums.mazums.ac.ir/article-1-16758-en.html |
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