MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation

MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation

Abstract Male‐specific lethal 1 (MSL1) is critical for the formation of MSL histone acetyltransferase complex which acetylates histone H4 Lys16 (H4K16ac) to activate gene expression. However, the role of MSL1 in liver regeneration is poorly understood. Here, this work identifies MSL1 as a key regula...

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Bibliographic Details
Main Authors: Yucheng He, Shichao Wang, Shenghui Liu, Dan Qin, Zhangmei Liu, Liqiang Wang, Xiangmei Chen, Lisheng Zhang
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
acetyl coenzyme A
histone H4
liquid–liquid phase separation
liver regeneration
MSL1
STAT3
Online Access:https://doi.org/10.1002/advs.202301094

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