Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT intervalResearch in context

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT intervalResearch in context

Summary: Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes. Therefore, there is a need to identify factors influencing disease severity to move towards an individualized c...

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Bibliographic Details
Main Authors: Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:EBioMedicine
Subjects:
Arrhythmia
Electrophysiology
KCNQ1
Kv7
Long QT Syndrome
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423000245

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