Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease
Abstract Background We aimed to investigate the clinical correlates of principal components (PCs) of tau positron emission tomography (PET) and their predictability for longitudinal changes in tau accumulation in Alzheimer’s disease (AD). Methods We enrolled 272 participants who underwent two PET sc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13195-020-00685-4 |
| _version_ | 1818414991438512128 |
|---|---|
| author | Hanna Cho Min Seok Baek Hye Sun Lee Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo |
| author_facet | Hanna Cho Min Seok Baek Hye Sun Lee Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo |
| author_sort | Hanna Cho |
| collection | DOAJ |
| description | Abstract Background We aimed to investigate the clinical correlates of principal components (PCs) of tau positron emission tomography (PET) and their predictability for longitudinal changes in tau accumulation in Alzheimer’s disease (AD). Methods We enrolled 272 participants who underwent two PET scans [18F-flortaucipir for tau and 18F-florbetaben for amyloid-β (Aβ)], brain magnetic resonance imaging, and neuropsychological tests as baseline assessments. Among them, 187 participants underwent the same follow-up assessments after an average of 2 years. Using Aβ-positive AD dementia-specific PCs obtained from the baseline scans of 56 Aβ-positive patients with AD dementia, we determined the expression of the first two PCs (PC1 and PC2) in all participants. We assessed the correlation of PC expression with baseline clinical characteristics and tau accumulation rates. Moreover, we investigated the predictability of PCs for the longitudinal tau accumulation in training and test sets. Results PC1 corresponded to the tau distribution pattern in AD, while the two PC2 extremes reflected the parietal or temporal predominance of tau distribution. PC1 expression increased with tau burden and decreased with cognitive impairment, while PC2 expression decreased with advanced age and visuospatial and attention function deterioration. The tau accumulation rate was positively correlated with PC1 expression (greater tau burden) and negatively correlated with PC2 expression (temporal predominance). A regression model using both PCs could predict longitudinal changes in the tau burden (intraclass correlation coefficient = 0.775, R 2 = 0.456 in test set). Conclusions PC analysis of tau PET could be useful for evaluating disease progression, characterizing the tau distribution pattern, and predicting longitudinal tau accumulation. |
| first_indexed | 2024-12-14T11:27:53Z |
| format | Article |
| id | doaj.art-68cce434044b468d85bbe64c54041c90 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-14T11:27:53Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-68cce434044b468d85bbe64c54041c902022-12-21T23:03:25ZengBMCAlzheimer’s Research & Therapy1758-91932020-09-0112111110.1186/s13195-020-00685-4Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s diseaseHanna Cho0Min Seok Baek1Hye Sun Lee2Jae Hoon Lee3Young Hoon Ryu4Chul Hyoung Lyoo5Department of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineBiostatistics Collaboration Unit, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract Background We aimed to investigate the clinical correlates of principal components (PCs) of tau positron emission tomography (PET) and their predictability for longitudinal changes in tau accumulation in Alzheimer’s disease (AD). Methods We enrolled 272 participants who underwent two PET scans [18F-flortaucipir for tau and 18F-florbetaben for amyloid-β (Aβ)], brain magnetic resonance imaging, and neuropsychological tests as baseline assessments. Among them, 187 participants underwent the same follow-up assessments after an average of 2 years. Using Aβ-positive AD dementia-specific PCs obtained from the baseline scans of 56 Aβ-positive patients with AD dementia, we determined the expression of the first two PCs (PC1 and PC2) in all participants. We assessed the correlation of PC expression with baseline clinical characteristics and tau accumulation rates. Moreover, we investigated the predictability of PCs for the longitudinal tau accumulation in training and test sets. Results PC1 corresponded to the tau distribution pattern in AD, while the two PC2 extremes reflected the parietal or temporal predominance of tau distribution. PC1 expression increased with tau burden and decreased with cognitive impairment, while PC2 expression decreased with advanced age and visuospatial and attention function deterioration. The tau accumulation rate was positively correlated with PC1 expression (greater tau burden) and negatively correlated with PC2 expression (temporal predominance). A regression model using both PCs could predict longitudinal changes in the tau burden (intraclass correlation coefficient = 0.775, R 2 = 0.456 in test set). Conclusions PC analysis of tau PET could be useful for evaluating disease progression, characterizing the tau distribution pattern, and predicting longitudinal tau accumulation.http://link.springer.com/article/10.1186/s13195-020-00685-4Alzheimer’s diseasePositron emission tomographyTau18F-flortaucipir |
| spellingShingle | Hanna Cho Min Seok Baek Hye Sun Lee Jae Hoon Lee Young Hoon Ryu Chul Hyoung Lyoo Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease Alzheimer’s Research & Therapy Alzheimer’s disease Positron emission tomography Tau 18F-flortaucipir |
| title | Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease |
| title_full | Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease |
| title_fullStr | Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease |
| title_full_unstemmed | Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease |
| title_short | Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer’s disease |
| title_sort | principal components of tau positron emission tomography and longitudinal tau accumulation in alzheimer s disease |
| topic | Alzheimer’s disease Positron emission tomography Tau 18F-flortaucipir |
| url | http://link.springer.com/article/10.1186/s13195-020-00685-4 |
| work_keys_str_mv | AT hannacho principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease AT minseokbaek principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease AT hyesunlee principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease AT jaehoonlee principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease AT younghoonryu principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease AT chulhyounglyoo principalcomponentsoftaupositronemissiontomographyandlongitudinaltauaccumulationinalzheimersdisease |