UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis. The major reason is that most GBM patients are resistant t...

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Bibliographic Details
Main Authors: Changyong Wu, Yang Shen, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Rutong Yu, Xuejiao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
GBM
TAK-243
radiosensitization
DNA damage repair
cell apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1073929/full

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