Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.

Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.

Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet. Angulins and tricellulin are known as specific protein component...

Full description

Bibliographic Details
Main Authors:	Tomohito Higashi, Tatsuya Katsuno, Shin-Ichiro Kitajiri, Mikio Furuse
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4378975?pdf=render

Similar Items

Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain.
by: Nayoung K D Kim, et al.
Published: (2015-01-01)

The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma
by: Hiroshi Shimada, et al.
Published: (2021-12-01)

Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells
by: Shin-ichiro Kitajiri, et al.
Published: (2014-07-01)

Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1
by: Yueyue Liu, et al.
Published: (2017-08-01)

Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland
by: Atsuko Y. Higashi, et al.
Published: (2021-11-01)

Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis
by: Jia-Chen E. Hu, et al.
Published: (2021-03-01)

Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions.
by: Daiki Nakatsu, et al.
Published: (2019-01-01)

Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells
by: Kizuku Ohwada, et al.
Published: (2021-08-01)

Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M)
by: Karem Awad, et al.
Published: (2023-01-01)

ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42
by: Qing Sang, et al.
Published: (2015-03-01)

Angulin-1 (LSR) Affects Paracellular Water Transport, However Only in Tight Epithelial Cells
by: Carlos Ayala-Torres, et al.
Published: (2021-07-01)

The Role of Tricellulin in Epithelial Jamming and Unjamming via Segmentation of Tricellular Junctions
by: Sophie Lohmann, et al.
Published: (2020-08-01)

Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis.
by: Yushi Hayashi, et al.
Published: (2021-01-01)

Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells
by: Mikio Furuse, et al.
Published: (2022-12-01)

Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
by: Shinsaku Tokuda, et al.
Published: (2015-01-01)

ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
by: Shinsaku Tokuda, et al.
Published: (2014-01-01)

Leptin Downregulates Angulin-1 in Active Crohn’s Disease via STAT3
by: Jia-Chen E. Hu, et al.
Published: (2020-10-01)

Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium.
by: Hongyuan Zheng, et al.
Published: (2022-06-01)

Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
by: Shinsaku Tokuda, et al.
Published: (2017-01-01)

Tight Junction barriers in human hair follicles – role of claudin-1
by: Michaela Zorn-Kruppa, et al.
Published: (2018-08-01)

Analyses of the expression and prognosis of ILDR1 in human gastric cancer
by: Li Wang, et al.
Published: (2022-09-01)

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape
by: Mariko Yokouchi, et al.
Published: (2016-11-01)

Cochlear Implants: Technology for the Profoundly Deaf
by: Catherine R George
Published: (1993-11-01)

Cochlear implants: implications for deaf identities
by: Irene W. Leigh, et al.
Published: (2014-06-01)

Tight junctions /
by: Gonzalez-Mariscal, Lorenza
Published: (2006)

The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184
by: Sharifkhodaei, Z, et al.
Published: (2016)

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.
by: Rashmi Chandra, et al.
Published: (2022-01-01)

ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.
by: Kazuhisa Watanabe, et al.
Published: (2013-01-01)

The management of deafness with cochlear implant – our experience
by: Jagoda Vatovec, et al.
Published: (2005-11-01)

Cochlear implant application with postlingually deaf patients
by: Kosanović Rade, et al.
Published: (2004-01-01)

Attitude of deaf culture toward cochlear implantation
by: Radić-Šestić Marina, et al.
Published: (2015-01-01)

Effect of radiological grade of cochlear ossification on cochlear implant outcome in postmeningitis deafness
by: Farid Alzhrani, et al.
Published: (2022-01-01)

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions
by: Alexis J. Haas, et al.
Published: (2022-11-01)

ILDR1 promotes influenza A virus replication through binding to PLSCR1
by: Yueyue Liu, et al.
Published: (2022-05-01)

Deaf or deaf? Questioning alleged antinomies in the bioethical discourses on cochlear implantation and suggesting an alternative approach to d/Deafness
by: Patrick Kermit
Published: (2009-07-01)

Made to hear: cochlear implants and raising deaf children
by: Sasha Scambler
Published: (2018-04-01)

Experience of Stages of Cochlear Implantation by Mothers of Deaf Children
by: Budantsov A.V., et al.
Published: (2019-12-01)

The use of nouns by deaf students and students with cochlear implant
by: Bojana Globačnik
Published: (2017-03-01)

Cognitive functioning in Deaf children using Cochlear implants
by: Fidaa Almomani, et al.
Published: (2021-02-01)

Balance Performance of Deaf Children With and Without Cochlear Implants
by: Amir-Abbas Ebrahimi, et al.
Published: (2016-12-01)