The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations
Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAF...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-024-03192-0 |
| _version_ | 1797259215235973120 |
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| author | Ziyan Feng Fanrong Zhao Ziyao Wang Xinyi Tang Yan Xie Li Qiu |
| author_facet | Ziyan Feng Fanrong Zhao Ziyao Wang Xinyi Tang Yan Xie Li Qiu |
| author_sort | Ziyan Feng |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and sarcopenia in young and middle-aged individuals in this study. Methods A total of 2214 individuals with laboratory tests, dual-energy X-ray absorptiometry and ultrasound transient elastography from NHANES 2017–2018 were selected for this study. MAFLD was diagnosed as fatty liver disease with any one of the situations: overweight/obesity, diabetes mellitus, presence of metabolic dysregulation. Sarcopenia was defined by appendicular lean mass adjusted for body mass index (BMI). Multivariable logistic regression and restricted cubic spline (RCS) model were applied to explore the relationship between MAFLD and sarcopenia, and the mediation analyses were also conducted. Moreover, subgroup analyses stratified by BMI and lifestyles were done. Results The prevalence of MAFLD was 47.85%, and nearly 8.05% of participants had sarcopenia. The prevalence of sarcopenia was higher in participants with MAFLD (12.75%; 95% CI 10.18–15.31%) than in the non-MAFLD (3.73%; 95% CI 2.16–5.31%). MAFLD was significantly positively associated with sarcopenia after adjustments [OR = 2.87 (95% CI: 1.62–5.09)]. Moreover, significant positive associations were observed between liver fibrosis and sarcopenia prevalence in MAFLD patients (OR = 2.16; 95% CI 1.13–4.15). The RCS curve revealed that MAFLD was linearly associated with sarcopenia. The relationship between the MAFLD and sarcopenia were mediated by C-reactive protein (mediation proportion: 15.9%) and high-density lipoprotein cholesterol (mediation proportion: 18.9%). Subgroup analyses confirmed the association between MAFLD and sarcopenia differed in different lifestyle groups. Conclusions Both MAFLD prevalence and severity was significantly associated with sarcopenia. Thus, clinicians should advise comorbidity screening and lifestyle changes to young and middle-aged patients. |
| first_indexed | 2024-04-24T23:05:53Z |
| format | Article |
| id | doaj.art-68ce7eaba1f842a6932d5410677abbf1 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-24T23:05:53Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-68ce7eaba1f842a6932d5410677abbf12024-03-17T12:27:58ZengBMCBMC Gastroenterology1471-230X2024-03-0124111110.1186/s12876-024-03192-0The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populationsZiyan Feng0Fanrong Zhao1Ziyao Wang2Xinyi Tang3Yan Xie4Li Qiu5Department of Medical Ultrasound and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of gastroenterology, West China Hospital, Sichuan UniversityDepartment of Medical Ultrasound and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Medical Ultrasound and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of gastroenterology, West China Hospital, Sichuan UniversityDepartment of Medical Ultrasound and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityAbstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and sarcopenia in young and middle-aged individuals in this study. Methods A total of 2214 individuals with laboratory tests, dual-energy X-ray absorptiometry and ultrasound transient elastography from NHANES 2017–2018 were selected for this study. MAFLD was diagnosed as fatty liver disease with any one of the situations: overweight/obesity, diabetes mellitus, presence of metabolic dysregulation. Sarcopenia was defined by appendicular lean mass adjusted for body mass index (BMI). Multivariable logistic regression and restricted cubic spline (RCS) model were applied to explore the relationship between MAFLD and sarcopenia, and the mediation analyses were also conducted. Moreover, subgroup analyses stratified by BMI and lifestyles were done. Results The prevalence of MAFLD was 47.85%, and nearly 8.05% of participants had sarcopenia. The prevalence of sarcopenia was higher in participants with MAFLD (12.75%; 95% CI 10.18–15.31%) than in the non-MAFLD (3.73%; 95% CI 2.16–5.31%). MAFLD was significantly positively associated with sarcopenia after adjustments [OR = 2.87 (95% CI: 1.62–5.09)]. Moreover, significant positive associations were observed between liver fibrosis and sarcopenia prevalence in MAFLD patients (OR = 2.16; 95% CI 1.13–4.15). The RCS curve revealed that MAFLD was linearly associated with sarcopenia. The relationship between the MAFLD and sarcopenia were mediated by C-reactive protein (mediation proportion: 15.9%) and high-density lipoprotein cholesterol (mediation proportion: 18.9%). Subgroup analyses confirmed the association between MAFLD and sarcopenia differed in different lifestyle groups. Conclusions Both MAFLD prevalence and severity was significantly associated with sarcopenia. Thus, clinicians should advise comorbidity screening and lifestyle changes to young and middle-aged patients.https://doi.org/10.1186/s12876-024-03192-0SarcopeniaMetabolic dysfunction-associated fatty liver diseaseLiver fibrosisObesity |
| spellingShingle | Ziyan Feng Fanrong Zhao Ziyao Wang Xinyi Tang Yan Xie Li Qiu The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations BMC Gastroenterology Sarcopenia Metabolic dysfunction-associated fatty liver disease Liver fibrosis Obesity |
| title | The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations |
| title_full | The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations |
| title_fullStr | The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations |
| title_full_unstemmed | The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations |
| title_short | The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations |
| title_sort | relationship between sarcopenia and metabolic dysfunction associated fatty liver disease among the young and middle aged populations |
| topic | Sarcopenia Metabolic dysfunction-associated fatty liver disease Liver fibrosis Obesity |
| url | https://doi.org/10.1186/s12876-024-03192-0 |
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