Frontal GABA levels change during working memory.
Functional neuroimaging metrics are thought to reflect changes in neurotransmitter flux, but changes in neurotransmitter levels have not been demonstrated in humans during a cognitive task, and the relationship between neurotransmitter dynamics and hemodynamic activity during cognition has not yet b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3317667?pdf=render |
| _version_ | 1818338376382676992 |
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| author | Lars Michels Ernst Martin Peter Klaver Richard Edden Fernando Zelaya David J Lythgoe Rafael Lüchinger Daniel Brandeis Ruth L O'Gorman |
| author_facet | Lars Michels Ernst Martin Peter Klaver Richard Edden Fernando Zelaya David J Lythgoe Rafael Lüchinger Daniel Brandeis Ruth L O'Gorman |
| author_sort | Lars Michels |
| collection | DOAJ |
| description | Functional neuroimaging metrics are thought to reflect changes in neurotransmitter flux, but changes in neurotransmitter levels have not been demonstrated in humans during a cognitive task, and the relationship between neurotransmitter dynamics and hemodynamic activity during cognition has not yet been established. We evaluate the concentration of the major inhibitory (GABA) and excitatory (glutamate + glutamine: Glx) neurotransmitters and the cerebral perfusion at rest and during a prolonged delayed match-to-sample working memory task. Resting GABA levels in the dorsolateral prefrontal cortex correlated positively with the resting perfusion and inversely with the change in perfusion during the task. Further, only GABA increased significantly during the first working memory run and then decreased continuously across subsequent task runs. The decrease of GABA over time was paralleled by a trend towards decreased reaction times and higher task accuracy. These results demonstrate a link between neurotransmitter dynamics and hemodynamic activity during working memory, indicating that functional neuroimaging metrics depend on the balance of excitation and inhibition required for cognitive processing. |
| first_indexed | 2024-12-13T15:10:08Z |
| format | Article |
| id | doaj.art-68d052d5552b4500a3675e508f04df97 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:10:08Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-68d052d5552b4500a3675e508f04df972022-12-21T23:40:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3193310.1371/journal.pone.0031933Frontal GABA levels change during working memory.Lars MichelsErnst MartinPeter KlaverRichard EddenFernando ZelayaDavid J LythgoeRafael LüchingerDaniel BrandeisRuth L O'GormanFunctional neuroimaging metrics are thought to reflect changes in neurotransmitter flux, but changes in neurotransmitter levels have not been demonstrated in humans during a cognitive task, and the relationship between neurotransmitter dynamics and hemodynamic activity during cognition has not yet been established. We evaluate the concentration of the major inhibitory (GABA) and excitatory (glutamate + glutamine: Glx) neurotransmitters and the cerebral perfusion at rest and during a prolonged delayed match-to-sample working memory task. Resting GABA levels in the dorsolateral prefrontal cortex correlated positively with the resting perfusion and inversely with the change in perfusion during the task. Further, only GABA increased significantly during the first working memory run and then decreased continuously across subsequent task runs. The decrease of GABA over time was paralleled by a trend towards decreased reaction times and higher task accuracy. These results demonstrate a link between neurotransmitter dynamics and hemodynamic activity during working memory, indicating that functional neuroimaging metrics depend on the balance of excitation and inhibition required for cognitive processing.http://europepmc.org/articles/PMC3317667?pdf=render |
| spellingShingle | Lars Michels Ernst Martin Peter Klaver Richard Edden Fernando Zelaya David J Lythgoe Rafael Lüchinger Daniel Brandeis Ruth L O'Gorman Frontal GABA levels change during working memory. PLoS ONE |
| title | Frontal GABA levels change during working memory. |
| title_full | Frontal GABA levels change during working memory. |
| title_fullStr | Frontal GABA levels change during working memory. |
| title_full_unstemmed | Frontal GABA levels change during working memory. |
| title_short | Frontal GABA levels change during working memory. |
| title_sort | frontal gaba levels change during working memory |
| url | http://europepmc.org/articles/PMC3317667?pdf=render |
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