The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
Abstract N6-methyladenosine(m6A) is one of the most abundant modifications of mammalian cellular RNAs. m6A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-05-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00695-2 |
| _version_ | 1797817914387070976 |
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| author | Zhihua Lv Ruoxi Ran Yuting Yang Meixian Xiang Hanwen Su Jingtao Huang |
| author_facet | Zhihua Lv Ruoxi Ran Yuting Yang Meixian Xiang Hanwen Su Jingtao Huang |
| author_sort | Zhihua Lv |
| collection | DOAJ |
| description | Abstract N6-methyladenosine(m6A) is one of the most abundant modifications of mammalian cellular RNAs. m6A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m6A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m6A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease. |
| first_indexed | 2024-03-13T09:00:30Z |
| format | Article |
| id | doaj.art-68d152943a90422db679805355bddc5e |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-03-13T09:00:30Z |
| publishDate | 2023-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-68d152943a90422db679805355bddc5e2023-05-28T11:20:32ZengSpringerDiscover Oncology2730-60112023-05-0114111810.1007/s12672-023-00695-2The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanismsZhihua Lv0Ruoxi Ran1Yuting Yang2Meixian Xiang3Hanwen Su4Jingtao Huang5Department of Clinical Laboratory, Institute of Translational Medcine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medcine, Renmin Hospital of Wuhan UniversityDepartment of General Office, School of Stomatology, Wuhan UniversitySchool of Pharmaceutical Sciences, South-Central University for NationalitiesDepartment of Clinical Laboratory, Institute of Translational Medcine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medcine, Renmin Hospital of Wuhan UniversityAbstract N6-methyladenosine(m6A) is one of the most abundant modifications of mammalian cellular RNAs. m6A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m6A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m6A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease.https://doi.org/10.1007/s12672-023-00695-2m6ALiver diseaseMolecular mechanismsCarcinogenesis |
| spellingShingle | Zhihua Lv Ruoxi Ran Yuting Yang Meixian Xiang Hanwen Su Jingtao Huang The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms Discover Oncology m6A Liver disease Molecular mechanisms Carcinogenesis |
| title | The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms |
| title_full | The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms |
| title_fullStr | The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms |
| title_full_unstemmed | The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms |
| title_short | The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms |
| title_sort | interplay between n6 methyladenosine and precancerous liver disease molecular functions and mechanisms |
| topic | m6A Liver disease Molecular mechanisms Carcinogenesis |
| url | https://doi.org/10.1007/s12672-023-00695-2 |
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