β-Dystroglycan Restoration and Pathology Progression in the Dystrophic <i>mdx</i> Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation

β-Dystroglycan Restoration and Pathology Progression in the Dystrophic <i>mdx</i> Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation

ROS-activated cSrc tyrosine kinase (TK) promotes the degradation of β-dystroglycan (β-DG), a dystrophin-glycoprotein complex component, which may reinforce damaging signals in Duchenne muscular dystrophy (DMD). Therefore, cSrc-TK represents a promising therapeutic target. In <i>mdx</i> m...

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Bibliographic Details
Main Authors: Paola Mantuano, Brigida Boccanegra, Elena Conte, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Ornella Cappellari, Ilaria Arduino, Annalisa Cutrignelli, Angela Assunta Lopedota, Antonietta Mele, Nunzio Denora, Annamaria De Luca
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomolecules
Subjects:
Duchenne muscular dystrophy
preclinical study
<i>mdx</i> mouse
dasatinib
cyclodextrin
oral formulation
Online Access:https://www.mdpi.com/2218-273X/11/11/1742

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