The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis
Aim: In this study; we investigated the effects of atorvastatin treatment on endothelial dysfunction (ED) as well as antihyperlipidemic effects of atorvastatin treatment in patients with hemodialysis due to end-stage renal disease for at least 6 months. Materials and Method: In this study, 15 contro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2019-04-01
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| Series: | Acta Medica Alanya |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/44836/511795?publisher=alku |
| _version_ | 1797922180331208704 |
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| author | Mustafa Etli̇ Turhan Yavuz Mustafa Kayan Mehmet Tuğrul Sezer |
| author_facet | Mustafa Etli̇ Turhan Yavuz Mustafa Kayan Mehmet Tuğrul Sezer |
| author_sort | Mustafa Etli̇ |
| collection | DOAJ |
| description | Aim: In this study; we investigated the effects of atorvastatin treatment on endothelial dysfunction (ED) as well as antihyperlipidemic effects of atorvastatin treatment in patients with hemodialysis due to end-stage renal disease for at least 6 months. Materials and Method: In this study, 15 control and 15 atorvastatin patients were examined. Evaluation of ED was performed by evaluating the flow-mediated dilatation of the brachial artery in the fistula which was performed as described previously. Results: Comparing the first and last value difference of LDL with independent T-test for statin given and not given groups; LDL values were statistically significant in statin group (p = 0.000, p <0.01). In addition, the comparison of the first and last value difference of FMD with the independent T-test according to statin given and not given groups: According to the statin group, the FMD values were statistically significant (p = 0.001, p <0.01).
Conclusion: In our study, we applied FMD test results to demonstrate endothelial dysfunction; i) statin group is statistically significant in favor of statin group compared to control group, ii) fistula development and patency rate is statistically more meaningful in statin group due to decrease in atherosclerosis development. In view of these findings, we believe that statin use is necessary to ensure short-term fistula patency in statin AVF patients and to protect the dialysis access path without the need for additional processing. |
| first_indexed | 2024-04-10T14:27:23Z |
| format | Article |
| id | doaj.art-68d8cebf506f45f08861a3ea7400d085 |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T14:27:23Z |
| publishDate | 2019-04-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-68d8cebf506f45f08861a3ea7400d0852023-02-15T16:09:00ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192019-04-0131273210.30565/medalanya.511795727The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for HemodialysisMustafa Etli̇Turhan Yavuz0Mustafa Kayan1Mehmet Tuğrul Sezer2SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİSÜLEYMAN DEMİREL ÜNİVERSİTESİSÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİAim: In this study; we investigated the effects of atorvastatin treatment on endothelial dysfunction (ED) as well as antihyperlipidemic effects of atorvastatin treatment in patients with hemodialysis due to end-stage renal disease for at least 6 months. Materials and Method: In this study, 15 control and 15 atorvastatin patients were examined. Evaluation of ED was performed by evaluating the flow-mediated dilatation of the brachial artery in the fistula which was performed as described previously. Results: Comparing the first and last value difference of LDL with independent T-test for statin given and not given groups; LDL values were statistically significant in statin group (p = 0.000, p <0.01). In addition, the comparison of the first and last value difference of FMD with the independent T-test according to statin given and not given groups: According to the statin group, the FMD values were statistically significant (p = 0.001, p <0.01). Conclusion: In our study, we applied FMD test results to demonstrate endothelial dysfunction; i) statin group is statistically significant in favor of statin group compared to control group, ii) fistula development and patency rate is statistically more meaningful in statin group due to decrease in atherosclerosis development. In view of these findings, we believe that statin use is necessary to ensure short-term fistula patency in statin AVF patients and to protect the dialysis access path without the need for additional processing.https://dergipark.org.tr/en/pub/medalanya/issue/44836/511795?publisher=alkuhemodiyalizstatinlerendotelyal disfonksiyonhemodiyalizstatinlerendothelial dysfunction |
| spellingShingle | Mustafa Etli̇ Turhan Yavuz Mustafa Kayan Mehmet Tuğrul Sezer The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis Acta Medica Alanya hemodiyaliz statinler endotelyal disfonksiyon hemodiyaliz statinler endothelial dysfunction |
| title | The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis |
| title_full | The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis |
| title_fullStr | The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis |
| title_full_unstemmed | The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis |
| title_short | The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis |
| title_sort | effect of statins on the developing endotal dysfunction in arterioveneic fistules opening for hemodialysis |
| topic | hemodiyaliz statinler endotelyal disfonksiyon hemodiyaliz statinler endothelial dysfunction |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/44836/511795?publisher=alku |
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