Time-related sex differences in cerebral hypoperfusion-induced brain injury
Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been clearly identified. In the current study, we examined whether cerebral h...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2014-01-01
|
| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641404673S.pdf |
| Summary: | Although the model of cerebral hypoperfusion in rats has been a matter of
many investigations over the years, the exact intracellular and biochemical
mechanisms that lead to neuron loss and memory decline have not been clearly
identified. In the current study, we examined whether cerebral hypoperfusion
causes changes in hippocampal protein expression of apoptotic markers in the
synaptosomal fraction and neurodegeneration in a time-dependent and
sex-specific manner. Adult male and female Wistar rats were divided into two
main groups, controls that underwent sham operation, and animals subjected to
permanent bilateral occlusion of common carotid arteries. Both male and
female rats were killed 3, 7 or 90 days following the insult. The obtained
results indicate that the peak of processes that lead to apoptosis occured on
postoperative day 7 and that they were more prominent in males, indicating
that neuroprotective effects of certain substances (planned for future
experiments), should be tested at this time point. [Projekat Ministarstva
nauke Republike Srbije, br. 173044 i br. 41014] |
|---|---|
| ISSN: | 0354-4664 1821-4339 |