Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health
Despite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1122422/full |
| _version_ | 1811164300776046592 |
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| author | Choong Yong Ung Cristina Correia Daniel Denis Billadeau Shizhen Zhu Shizhen Zhu Hu Li |
| author_facet | Choong Yong Ung Cristina Correia Daniel Denis Billadeau Shizhen Zhu Shizhen Zhu Hu Li |
| author_sort | Choong Yong Ung |
| collection | DOAJ |
| description | Despite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enhance regenerative health and improve patient care. Epigenetics represents one of the major biological mechanisms involving in tissue regeneration, and therefore can be viewed as a systemic (body-wide) control. However, how epigenetic regulations concertedly lead to the development of biological memories at the whole-body level remains unclear. Here, we review the evolving definitions of epigenetics and identify missing links. We then propose our Manifold Epigenetic Model (MEMo) as a conceptual framework to explain how epigenetic memory arises and discuss what strategies can be applied to manipulate the body-wide memory. In summary we provide a conceptual roadmap for the development of new engineering approaches to improve regenerative health. |
| first_indexed | 2024-04-10T15:19:24Z |
| format | Article |
| id | doaj.art-68db4c70e25b44299fb340360b6c6137 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T15:19:24Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-68db4c70e25b44299fb340360b6c61372023-02-14T16:18:16ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.11224221122422Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative healthChoong Yong Ung0Cristina Correia1Daniel Denis Billadeau2Shizhen Zhu3Shizhen Zhu4Hu Li5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United StatesDepartment of Immunology, Mayo Clinic, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United StatesDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United StatesDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United StatesDespite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enhance regenerative health and improve patient care. Epigenetics represents one of the major biological mechanisms involving in tissue regeneration, and therefore can be viewed as a systemic (body-wide) control. However, how epigenetic regulations concertedly lead to the development of biological memories at the whole-body level remains unclear. Here, we review the evolving definitions of epigenetics and identify missing links. We then propose our Manifold Epigenetic Model (MEMo) as a conceptual framework to explain how epigenetic memory arises and discuss what strategies can be applied to manipulate the body-wide memory. In summary we provide a conceptual roadmap for the development of new engineering approaches to improve regenerative health.https://www.frontiersin.org/articles/10.3389/fcell.2023.1122422/fullregenerative healthagingmanifold epigeneticsepigenetics memorybody-wide phenotypesepigenetics |
| spellingShingle | Choong Yong Ung Cristina Correia Daniel Denis Billadeau Shizhen Zhu Shizhen Zhu Hu Li Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health Frontiers in Cell and Developmental Biology regenerative health aging manifold epigenetics epigenetics memory body-wide phenotypes epigenetics |
| title | Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health |
| title_full | Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health |
| title_fullStr | Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health |
| title_full_unstemmed | Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health |
| title_short | Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health |
| title_sort | manifold epigenetics a conceptual model that guides engineering strategies to improve whole body regenerative health |
| topic | regenerative health aging manifold epigenetics epigenetics memory body-wide phenotypes epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1122422/full |
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