BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish

BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish

The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide substitutions, which account for ~60% of human disease-c...

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Autors principals:	Blake Carrington, Rachel N. Weinstein, Raman Sood
Format:	Article
Idioma:	English
Publicat:	MDPI AG 2020-07-01
Col·lecció:	Cells
Matèries:	zebrafish base editing genome editing BE4max AncBE4max
Accés en línia:	https://www.mdpi.com/2073-4409/9/7/1690

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