Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications
Developing bioceramics-based nanomaterials for scaffolding is still a challenge. Three biocompatible materials are combined in one nanocomposite to fabricate antibacterial nanocomposite with higher mechanical properties. The nanocomposite contains hydroxyapatite (HAP), hematite (Fe2O3), and graphene...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422004367 |
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| author | Nasser S. Awwad Emad M. Eed Ahmad El Askary Hala A. Ibrahium Moustapha E. Moustapha M.K. Ahmed |
| author_facet | Nasser S. Awwad Emad M. Eed Ahmad El Askary Hala A. Ibrahium Moustapha E. Moustapha M.K. Ahmed |
| author_sort | Nasser S. Awwad |
| collection | DOAJ |
| description | Developing bioceramics-based nanomaterials for scaffolding is still a challenge. Three biocompatible materials are combined in one nanocomposite to fabricate antibacterial nanocomposite with higher mechanical properties. The nanocomposite contains hydroxyapatite (HAP), hematite (Fe2O3), and graphene oxide. The nanocomposite is examined chemically, structurally, and in vitro. The structural investigations showed a second minor phase with Fe2O3 which is FeO(OH). TEM investigated the shape morphology. There are two types of nanorods are detected which are small ones that belong to HAP, and long nanorods that belong to Fe2O3. Further, the nanosheets of GO are determined in addition to nano ellipsoids of FeOOH. The surface roughness is enhanced and Rq raised from 4.6 to 5.3 from pure HAP to HAP/Fe2O3/GO. The released ions rate of Fe3+ was constant for the first and second 12 h with a value of 2 ppm/h. The rate of Ca2+ decreased from 8 to 2.25 ppm/h for the first and second 12 h. Moreover, mechanical properties are enhanced and microhardness increased from 2.5 ± 0.1 to 3.1 ± 0.2 GPa. In addition, the shear modulus changed from 16.503 ± 1 to 20.45 ± 0.1 GPa. The antibacterial properties enhanced against Escherichia coli and Staphylococcus aureus and reached 16.5 ± 0.5 and 17.2 ± 0.7 mm without showing cytotoxicity toward the human osteoblast cells. |
| first_indexed | 2024-12-12T04:13:45Z |
| format | Article |
| id | doaj.art-68dc0d3175d04b9587528198a09f75cc |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-12T04:13:45Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-68dc0d3175d04b9587528198a09f75cc2022-12-22T00:38:32ZengElsevierJournal of Materials Research and Technology2238-78542022-05-011843404352Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applicationsNasser S. Awwad0Emad M. Eed1Ahmad El Askary2Hala A. Ibrahium3Moustapha E. Moustapha4M.K. Ahmed5Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia; Department of Semi Pilot Plant, Nuclear Materials Authority, P.O. Box 530, El Maadi, EgyptDepartment of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi ArabiaFaculty of Nanotechnology for Postgraduate Studies, Cairo University, El-Sheikh Zayed, 12588, Egypt; Department of Physics, Faculty of Science, Suez University, Suez, 43518, Egypt; Corresponding author.Developing bioceramics-based nanomaterials for scaffolding is still a challenge. Three biocompatible materials are combined in one nanocomposite to fabricate antibacterial nanocomposite with higher mechanical properties. The nanocomposite contains hydroxyapatite (HAP), hematite (Fe2O3), and graphene oxide. The nanocomposite is examined chemically, structurally, and in vitro. The structural investigations showed a second minor phase with Fe2O3 which is FeO(OH). TEM investigated the shape morphology. There are two types of nanorods are detected which are small ones that belong to HAP, and long nanorods that belong to Fe2O3. Further, the nanosheets of GO are determined in addition to nano ellipsoids of FeOOH. The surface roughness is enhanced and Rq raised from 4.6 to 5.3 from pure HAP to HAP/Fe2O3/GO. The released ions rate of Fe3+ was constant for the first and second 12 h with a value of 2 ppm/h. The rate of Ca2+ decreased from 8 to 2.25 ppm/h for the first and second 12 h. Moreover, mechanical properties are enhanced and microhardness increased from 2.5 ± 0.1 to 3.1 ± 0.2 GPa. In addition, the shear modulus changed from 16.503 ± 1 to 20.45 ± 0.1 GPa. The antibacterial properties enhanced against Escherichia coli and Staphylococcus aureus and reached 16.5 ± 0.5 and 17.2 ± 0.7 mm without showing cytotoxicity toward the human osteoblast cells.http://www.sciencedirect.com/science/article/pii/S2238785422004367HematiteGraphene oxideHydroxyapatiteAntibacterialMechanical properties |
| spellingShingle | Nasser S. Awwad Emad M. Eed Ahmad El Askary Hala A. Ibrahium Moustapha E. Moustapha M.K. Ahmed Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications Journal of Materials Research and Technology Hematite Graphene oxide Hydroxyapatite Antibacterial Mechanical properties |
| title | Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications |
| title_full | Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications |
| title_fullStr | Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications |
| title_full_unstemmed | Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications |
| title_short | Development of nanocomposite based on hydroxyapatite/hematite/graphene oxide for medical applications |
| title_sort | development of nanocomposite based on hydroxyapatite hematite graphene oxide for medical applications |
| topic | Hematite Graphene oxide Hydroxyapatite Antibacterial Mechanical properties |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422004367 |
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