Osteofibrous dysplasia-like adamantinoma: A case report and literature review
Abstract backgroundOsteofibrous dysplasia-like adamantinoma (OFD-like adamantinoma), classical adamantinoma and dedifferentiated adamantinoma were previously considered to be three subtypes of adamantinoma of long bones. In the 5th edition of the World Health Organization (WHO) classification of bon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.967294/full |
| _version_ | 1798019219837681664 |
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| author | Jian-Wei Li Lei Miao Zhen-Guo Zhao Lin Yang Zhuo Shi Meng Li |
| author_facet | Jian-Wei Li Lei Miao Zhen-Guo Zhao Lin Yang Zhuo Shi Meng Li |
| author_sort | Jian-Wei Li |
| collection | DOAJ |
| description | Abstract backgroundOsteofibrous dysplasia-like adamantinoma (OFD-like adamantinoma), classical adamantinoma and dedifferentiated adamantinoma were previously considered to be three subtypes of adamantinoma of long bones. In the 5th edition of the World Health Organization (WHO) classification of bone tumors in 2020, OFD-like adamantinoma was newly proposed and classified as an intermediate-locally aggressive tumor in other mesenchymal tumors of bone. OFD-like adamantinoma is rare, accounting for only 0.4% of all primary bone tumors. OFD-like adamantinoma is often misdiagnosed due to the insufficient understanding of it. Here we report a case of OFD-like adamantinoma treated in our hospital with a literature review.Case presentationThe patient, a 14-year-old male, had swelling in his right leg with intermittent pain for one year. Plain radiography, computed tomography (CT) and magnetic resonance imaging (MRI) were performed. Based on the radiological and histological examinations, a diagnosis of OFD-like adamantinoma was suspected. After admission, the patient underwent tumor resection of the right tibia, free transplantation of the left fibula and internal fixation. After resection of the tumor, the wound recovered well, the vital signs were stable, and activity was normal. The patient has been followed up for more than a year with no recurrence or distant metastasis.ConclusionOFD-like adamantinoma is a rare primary bone tumor with nonspecific clinical features. Imaging examination can demonstrate the lesion and help diagnosis. The pathological discovery of epithelioid tissue is the key evidence for diagnosis. |
| first_indexed | 2024-04-11T16:36:53Z |
| format | Article |
| id | doaj.art-68dc1169ddf94d299d4ab0170bf84db0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T16:36:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-68dc1169ddf94d299d4ab0170bf84db02022-12-22T04:13:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.967294967294Osteofibrous dysplasia-like adamantinoma: A case report and literature reviewJian-Wei Li0Lei Miao1Zhen-Guo Zhao2Lin Yang3Zhuo Shi4Meng Li5Department of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Orthopaedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaAbstract backgroundOsteofibrous dysplasia-like adamantinoma (OFD-like adamantinoma), classical adamantinoma and dedifferentiated adamantinoma were previously considered to be three subtypes of adamantinoma of long bones. In the 5th edition of the World Health Organization (WHO) classification of bone tumors in 2020, OFD-like adamantinoma was newly proposed and classified as an intermediate-locally aggressive tumor in other mesenchymal tumors of bone. OFD-like adamantinoma is rare, accounting for only 0.4% of all primary bone tumors. OFD-like adamantinoma is often misdiagnosed due to the insufficient understanding of it. Here we report a case of OFD-like adamantinoma treated in our hospital with a literature review.Case presentationThe patient, a 14-year-old male, had swelling in his right leg with intermittent pain for one year. Plain radiography, computed tomography (CT) and magnetic resonance imaging (MRI) were performed. Based on the radiological and histological examinations, a diagnosis of OFD-like adamantinoma was suspected. After admission, the patient underwent tumor resection of the right tibia, free transplantation of the left fibula and internal fixation. After resection of the tumor, the wound recovered well, the vital signs were stable, and activity was normal. The patient has been followed up for more than a year with no recurrence or distant metastasis.ConclusionOFD-like adamantinoma is a rare primary bone tumor with nonspecific clinical features. Imaging examination can demonstrate the lesion and help diagnosis. The pathological discovery of epithelioid tissue is the key evidence for diagnosis.https://www.frontiersin.org/articles/10.3389/fonc.2022.967294/fullbone tumorosteofibrous dysplasia-like adamantinomaplain radiographycomputed tomographymagnetic resonance imaging |
| spellingShingle | Jian-Wei Li Lei Miao Zhen-Guo Zhao Lin Yang Zhuo Shi Meng Li Osteofibrous dysplasia-like adamantinoma: A case report and literature review Frontiers in Oncology bone tumor osteofibrous dysplasia-like adamantinoma plain radiography computed tomography magnetic resonance imaging |
| title | Osteofibrous dysplasia-like adamantinoma: A case report and literature review |
| title_full | Osteofibrous dysplasia-like adamantinoma: A case report and literature review |
| title_fullStr | Osteofibrous dysplasia-like adamantinoma: A case report and literature review |
| title_full_unstemmed | Osteofibrous dysplasia-like adamantinoma: A case report and literature review |
| title_short | Osteofibrous dysplasia-like adamantinoma: A case report and literature review |
| title_sort | osteofibrous dysplasia like adamantinoma a case report and literature review |
| topic | bone tumor osteofibrous dysplasia-like adamantinoma plain radiography computed tomography magnetic resonance imaging |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.967294/full |
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