The histone deacetylase HDAC4 regulates long-term memory in Drosophila.
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3857321?pdf=render |
| _version_ | 1818203951638511616 |
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| author | Helen L Fitzsimons Silvia Schwartz Fiona M Given Maxwell J Scott |
| author_facet | Helen L Fitzsimons Silvia Schwartz Fiona M Given Maxwell J Scott |
| author_sort | Helen L Fitzsimons |
| collection | DOAJ |
| description | A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an important structure for memory formation, resulted in a specific impairment in long-term courtship memory, but had no affect on short-term memory. Overexpression of an HDAC4 catalytic mutant also abolished LTM, suggesting a mode of action independent of catalytic activity. We found that overexpression of HDAC4 resulted in a redistribution of the transcription factor MEF2 from a relatively uniform distribution through the nucleus into punctate nuclear bodies, where it colocalized with HDAC4. As MEF2 has also been implicated in regulation of long-term memory, these data suggest that the repressive effects of HDAC4 on long-term memory may be through interaction with MEF2. In the same genetic background, we also found that RNAi-mediated knockdown of HDAC4 impairs long-term memory, therefore we demonstrate that HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation. |
| first_indexed | 2024-12-12T03:33:30Z |
| format | Article |
| id | doaj.art-68dc6b3800664782b664b57488cd6b93 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T03:33:30Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-68dc6b3800664782b664b57488cd6b932022-12-22T00:39:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8390310.1371/journal.pone.0083903The histone deacetylase HDAC4 regulates long-term memory in Drosophila.Helen L FitzsimonsSilvia SchwartzFiona M GivenMaxwell J ScottA growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an important structure for memory formation, resulted in a specific impairment in long-term courtship memory, but had no affect on short-term memory. Overexpression of an HDAC4 catalytic mutant also abolished LTM, suggesting a mode of action independent of catalytic activity. We found that overexpression of HDAC4 resulted in a redistribution of the transcription factor MEF2 from a relatively uniform distribution through the nucleus into punctate nuclear bodies, where it colocalized with HDAC4. As MEF2 has also been implicated in regulation of long-term memory, these data suggest that the repressive effects of HDAC4 on long-term memory may be through interaction with MEF2. In the same genetic background, we also found that RNAi-mediated knockdown of HDAC4 impairs long-term memory, therefore we demonstrate that HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation.http://europepmc.org/articles/PMC3857321?pdf=render |
| spellingShingle | Helen L Fitzsimons Silvia Schwartz Fiona M Given Maxwell J Scott The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS ONE |
| title | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| title_full | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| title_fullStr | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| title_full_unstemmed | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| title_short | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| title_sort | histone deacetylase hdac4 regulates long term memory in drosophila |
| url | http://europepmc.org/articles/PMC3857321?pdf=render |
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